Cutaneous B-Cell Lymphomas - 30/08/24

Doi : 10.1016/j.hoc.2024.05.017

Jennifer Villasenor-Park, MD, PhD ^a,^{^{1
Drs Villasenor-Park and Chung contributed equally to this study.}}, Jina Chung, MD ^b,^{^{1
Drs Villasenor-Park and Chung contributed equally to this study.}}, Ellen J. Kim, MD ^c,^⁎
^a Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Perelman Center for Advanced Medicine, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA
^b Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, 2 Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, USA
^c Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Perelman Center for Advanced Medicine, 3400 Civic Center Boulevard, Room 721, 7th floor, Philadelphia, PA 19104, USA

^∗Corresponding author.

Résumé

Primary cutaneous B-cell lymphomas represent a type of non-Hodgkin’s lymphoma of the skin without evidence of extracutaneous involvement at the time of diagnosis. According to the 2018 World Health Organization–the European Organization for Research and Treatment of Cancer classification, primary cutaneous B-cell lymphomas include primary cutaneous marginal zone lymphoma, primary cutaneous follicle center lymphoma, primary cutaneous diffuse large B-cell lymphoma, leg type, intravascular large B-cell lymphoma, and Epstein-Barr virus+ mucocutaneous ulcer (provisional). Herein, we provide a comprehensive review of the updated literature on these entities, including clinical presentation, histopathology, immunophenotype, molecular genetics, prognosis, and treatment.

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Keywords : Cutaneous B-cell lymphoma, PCBCL, PCMZL, PCFCL, PCDLBCL-leg type, IVLBCL, EBV⁺ mucocutaneous ulcer