Primary thyroid lymphoma: A multi-center retrospective review - 26/09/24
, Tim N. Beck c , Jill Knepprath a, d , Gustavo Romero-Velez c , Katherine B. Heiden a, c , Christopher R. McHenry a, b, ⁎ Abstract |
Background |
Primary thyroid lymphoma (PTL) is rare and diagnosis is challenging.
Methods |
We conducted a multicenter retrospective study of patients with PTL from 1990 to 2023 to determine method of diagnosis, treatment, and outcomes.
Results |
The study cohort included 31 patients with PTL; all had thyroid enlargement; 21 (68 %) had compressive symptoms, 11 (35 %) had hypothyroidism and 3 had (10 %) B symptoms. Diagnosis was established from incisional biopsy in 8 (26 %), needle biopsy in 4 (13 %), excisional lymph node biopsy in 1 (3 %), and thyroidectomy specimens in 18 (58 %). 15 (48 %) patients had Hashimoto thyroiditis. Treatment included chemotherapy in 19 (61 %); surgery alone in 7 (23 %); and radiation alone or with surgery in 5 (16 %) patients. One (3 %) patient recurred, and 4 (13 %) patients died after a median 4.2 years.
Conclusion |
Diagnosis of PTL was made in only 13 % of patients preoperatively. There may be opportunity for needle biopsy to facilitate earlier diagnosis and treatment.
Le texte complet de cet article est disponible en PDF.Highlights |
• | PTL is a heterogeneous malignancy and making the diagnosis is challenging. |
• | Tissue biopsy continues to be the mainstay for establishing a definitive diagnosis. |
• | Needle biopsies with ancillary testing may help establish diagnosis earlier. |
Keywords : Primary thyroid lymphoma, Non-Hodgkin's lymphoma, Diffuse large B-cell lymphoma, MALT lymphoma, Fine needle aspiration biopsy
Plan
Vol 237
Article 115927- novembre 2024 Retour au numéro
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