Postoperative pain scores and opioid use after standard bupivacaine vs. liposomal bupivacaine regional blocks for abdominal cancer surgery: A propensity score matched study - 26/09/24
Abstract |
Background |
Fascial plane blocks (FPBs) are widely used for abdominal surgery with the assumption that liposomal bupivacaine (LB) is more effective than standard bupivacaine (SB).
Methods |
This was a single-institution retrospective cohort study of patients administered FPBs with LB or SB + admixtures (dexamethasone/dexmedetomidine) for open abdominal cancer surgery. Propensity score matching generated a 2:1 (LB:SB) matched cohort. Opioid use (mg oral morphine equivalents, OME) and severe pain (≥3 pain scores ≥7 in a 24-h period) were compared.
Results |
Opioid use was >150 mg OME in 19.9 % (29/146) LB and 16.4 % (12/73) SB patients (p = 0.586). Severe pain was experienced by 44 % (64/146) LB and 53 % (39/73) SB patients (p = 0.198). On multivariable analysis, SB vs LB choice was not associated with high opioid volume >150 mg or severe pain.
Conclusions |
FPBs with standard bupivacaine were not associated with higher 72-h opioid use or more severe pain compared to liposomal bupivacaine.
Le texte complet de cet article est disponible en PDF.Graphical abstract |
Highlights |
• | Fascial plane blocks were performed with liposomal or standard bupivacaine. |
• | Propensity score matching based on surgical service and gender. |
• | No difference in opioid use or severe pain between bupivacaine formulations. |
• | This study suggests equipoise between liposomal and standard bupivacaine. |
Keywords : Regional anesthesia, Nerve block, Laparotomy, Abdominal surgery, Surgical oncology
Plan
Vol 237
Article 115770- novembre 2024 Retour au numéro
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