Optical coherence tomography-measured blood vessel characteristics of port-wine birthmarks by depth: A cross-sectional study - 18/10/24
Abstract |
Background |
Port-Wine Birthmarks (PWB) are congenital capillary malformations requiring multiple treatments. Optical coherence tomography (OCT), a noninvasive imaging technique, characterizes vessels in cutaneous vascular lesions, including PWBs.
Objective |
To assess variability in blood vessel characteristics within and between individual PWBs.
Methods |
OCT was used to measure blood vessel density (%) and modal vessel diameter (micrometers) at increments of 0.05 mm from the skin surface to a depth of 0.50 mm at several adjacent spots of single PWBs in this cross-sectional study. Average ratios of vessel density and diameter in affected to control skin were obtained for each PWB by averaging data for all spots within a lesion. Statistical analysis was performed with a linear mixed effects model using SPSS software (IBM Corporation).
Results |
There was great variability in vessel density and diameter within and between PWBs. Depths where average ratios of vessel density were consistently greater in affected to control skin were shallow, between 0.15 mm and 0.2 mm deep from the skin surface.
Limitations |
Small sample size and device’s inability to measure diameters smaller than 20 micrometers.
Conclusion |
There is variability in vessel density and diameter within and between PWBs. Individualized treatment planning guided by OCT mapping should be studied further.
Le texte complet de cet article est disponible en PDF.Key words : blood vessel density, blood vessel diameter, blood vessel, capillary malformation, imaging, nevus flammeus, OCT, optical coherence tomography, port-wine birthmark, port-wine stain, vascular anomaly, vascular characteristics, vascular malformation
Abbreviations used : D-OCT, OCT, PDL, PWB
Plan
| Funding sources: Supported by research grant and equipment from Michelson Diagnostics. |
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| Presented previously at the American Academy of Dermatology Annual Meeting in New Orleans, Louisiana (2023), the American Society for Lasers in Medicine and Surgery in Phoenix, Arizona (2023), and the Sturge-Weber Foundation International Research Network and Care Connect Network Conference virtually (2023 and 2024). |
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| IRB approval status: Reviewed and approved by the University of California, Irvine institutional review board (#2008-6307). |
Vol 91 - N° 5
P. 848-854 - novembre 2024 Retour au numéro
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