In this article, we discuss preoperative clinical evaluation, diagnostic considerations, and the role/choice of antibiotics. Operative planning is discussed with attention to patient characteristics/disease condition as they may inform consideration of alternative operative approaches. Detailed steps of laparoscopic, robotic–assisted, and open cholecystectomy are discussed. Indications and operative steps for intraoperative cholangiogram and laparoscopic transcystic common bile duct exploration are included. We conclude with postoperative care, including evaluation of common complications and necessary management considerations.