Biliary malignancy is rare, often carries poor prognosis, and most patients are not resection candidates at diagnosis. There are a variety of endoscopic, percutaneous, and systemic treatments that are used to address the symptoms and complications of biliary malignancy. Additionally, best supportive care and palliative care should be incorporated into care plans early on in a patient’s course. It is important for all physicians to be equipped to have conversations regarding overall prognosis, general expectations, and goals of care to determine a care plan individualized for each patient.