Accelerometer-measured physical activity in patients with heart failure and reduced ejection fraction: Determinants and relationship with patient-reported health status - 10/11/24
, Massar Omar, MD, PhD c, d, e, Julie Hempel Larsen, MD c, d, e, Caroline Kistorp, MD, PhD b, f, Christian Tuxen, MD, PhD g, Finn Gustafsson, MD, PhD, DMSc h, Lars Køber, MD, PhD h, Mikael Kjær Poulsen, MD, PhD c, Jan Christian Brønd, PhD i, Jacob Eifer Møller, MD, PhD, DMSc c, d, h, Morten Schou, MD, PhD a, b, Jesper Jensen, MD, PhD a, bABSTRACT |
Background |
Accelerometer-measured physical activity is an increasingly used endpoint in heart failure (HF) trials. We investigated the determinants of accelerometer-measured physical activity and the relationship with patient-reported health status.
Methods |
Post-hoc analysis of the Empire HF trial, including outpatients with HF with reduced ejection fraction (HFrEF). Physical activity was quantified as average accelerometer counts per minute (CPM) with higher values representing higher activity. We investigated associations between activity level and clinical variables, including age, sex, and body mass index, as well as patient-reported health status assessed by Kansas City Cardiomyopathy Questionnaire (KCCQ).
Results |
Complete data were available in 180 (95%) patients (86% male, mean age 65 year). Baseline median physical activity level was 1,318 CPM (Q1-Q3 1,111-1,585). Age and anemia were independently associated with activity level (β-coefficients: −10 CPM per year age increase [95% CI −16 to −5.1], P = .00015, and −126 CPM for anemia [95% CI −9.1 to −244], P = .035). Significant independent associations were observed between activity level and all KCCQ summary scores (β-coefficient point estimates of 3.7, 4.6, and 4.9 CPM, all P < .02). For 12-week changes in KCCQ-summary scores, only the KCCQ-CSS was associated with activity level; mean increase of 17.5 CPM [95% CI 1.5 to 34.0], P = 0.032, per 5-point increase in KCCQ-CSS. Associations were not modified by treatment allocation (interaction P-values > .05).
Conclusions |
In patients with HFrEF, older age and anemia were independently associated with lower activity. Moreover, physical activity only weakly increased with better health status, suggesting that changes in physical activity reflect improvements in patients’ health status to a limited degree. This highlights the need to better understand the endpoint with regards to all other health parameters to ease interpretation in future HF trials.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Plan
Vol 278
P. 14-23 - décembre 2024 Retour au numéro
Article précédent
- Safety and feasibility of triage and rapid discharge of patients with chest pain from emergency room: A pragmatic, randomized noninferiority control trial of the European Society of Cardiology (ESC) 0 to 1 hour pathway vs conventional 0 to 3 hour accelerated diagnostic protocol
- Aleem Khand, James Hatherley, Ahmed Dakshi, Guy Miller, Lisa Bailey, Michael Fisher, Christopher Goulden, Zaid Noori, Anju Rawat, Rachel Hornby, Hannah Fearon, Nirmol Meah, Sarah Davies, Katarzyna Sekulska, Awtad Hassan, Angela Lambert, Suzannah Phillips, Ray Raj, Tom Wiles, Paul Collinson
- Contributors to high left ventricular ejection fraction in women with ischemia and no obstructive coronary artery disease: Results from the Women's Ischemia Syndrome Evaluation—Coronary Vascular Dysfunction (WISE-CVD) Study
- Michael D. Nelson, Joanne M. Gomez-Arnold, Janet Wei, Marie Lauzon, Sauyeh K. Zamani, Jenna Maughan, Okezi Obrutu, Chrisandra Shufelt, Eileen Handberg, Carl Pepine, C. Noel Bairey Merz
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?