Fructose Consumption is Associated with a Higher Risk of Dementia and Alzheimer’s Disease: A Prospective Cohort Study - 21/11/24
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Abstract |
Background |
This study aimed to investigate the association between fructose consumption and all-cause dementia, and Alzheimer’s disease (AD) dementia.
Methods |
We used data from the Framingham Offspring Study (FOS) Cohort exams 5 through 9. Fructose consumption was quantified using a food-frequency questionnaire (FFQ) at cohort examinations 5 and participants were dementia-free at baseline. Surveillance for incident events commenced at examination 9 through 2014. Multivariable Cox proportional hazards regression was used to estimate the hazard ratios for the association between fructose consumption and incidence of all-cause dementia and AD dementia.
Results |
Over a mean follow-up of 15.2 (interquartile range, 12.3–17.1) years (31715.1 person-years), there were 233 dementia events of which 163 were AD dementia (70.0%). After multivariate adjustments, individuals with the highest consumption of fructose had a higher risk of all-cause dementia, and AD dementia when comparing daily cumulative consumption to 0 per week (reference), with HRs of 1.49 (95% 1.14–1.84, P for trend < 0.001) for all-cause dementia, and 1.60 (95%CI 1.22–2.01, P-trend < 0.001) for AD dementia. And the comparable results were shown in the subgroups for individuals with median consumption of fructose.
Conclusion |
Fructose consumption was associated with a higher risk of all-cause dementia and AD dementia.
Le texte complet de cet article est disponible en PDF.Key words : Fructose, dementia, Alzheimer’s disease, Framingham Offspring Study, risk factors
Plan
| Grant Support: None. |
Vol 10 - N° 2
P. 186-192 - avril 2023 Retour au numéro
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