Hypoglossal nerve stimulation for obstructive sleep apnea in adults: An updated systematic review and meta-analysis - 22/11/24
, Mohammad T. Abuawwad a, 1 , Mohammad J.J. Taha a , Mohammed Khurais a , Muhammad Sabrah Sayed a , Amneh M. Dahik a , Noha Keshk b, c , Sameh Abdelhadi a , Hashem Abu Serhan d, ⁎ Abstract |
Objectives |
This study aims to evaluate the efficacy of Apnex, Inspire, and ImThera hypoglossal nerve stimulation (HGNS) devices in changing the severity of obstructive sleep apnea (OSA).
Method |
ology: A systematic search was conducted across the databases to collect baseline and postoperative outcome measures. Articles were then filtered and data from post-filtration was extracted. The efficacy of each device was assessed individually, and the reported outcomes were analyzed at short-term (≤1 year) and long-term (>1 year) intervals.
Results |
A total of 30 papers were included; 26 were single-arm studies encompassing 549 middle-aged overweight patients. Four RCTs included 273 participants. Results show that HGNS is an effective and safe treatment option. The Inspire device significantly improved, reducing the apnea-hypopnea index (AHI) by −20.14 events/h in the short term and −15.91 events/h in the long term. It also decreased the oxygen desaturation index (ODI) by −14.16 events/h (short term) and −12.95 events/h (long term). Patient-reported outcomes showed decreased Epworth Sleepiness Scale (ESS) scores by −5.02 (short term) and −4.90 (long term) and improved Functional Outcomes of Sleep Questionnaire (FOSQ) scores by 3.58 (short term) and 3.28 (long term). The Apnex and the ImThera devices featured similar improvements but to a lesser extent.
Conclusion |
Hypoglossal nerve stimulation is a safe and effective treatment for patients with OSA, exhibiting high adherence and satisfaction rates. However, it is important to note the potential for refining selection criteria to include a wider spectrum of patients with OSA.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Hypoglossal Nerve Stimulation (HGNS) is a promising treatment for non-adherent or intolerant CPAP patients with moderate to severe OSA and a BMI of ≤ 32 kg/m². |
• | The Inspire device significantly reduced AHI by -20.14 events/h in the short term and -15.91 events/h in the long term. |
• | The Apnex device resulted in short-term reductions in AHI (-21.66 events/h), ODI (-6.38 events/h), and ESS (-4.13), with a 2.59 improvement in FOSQ score. |
• | Hypoglossal nerve stimulation is a safe and effective treatment for patients with OSA, exhibiting high adherence and satisfaction rates. |
Keywords : Hypoglossal nerve stimulation, Upper airway stimulation, Obstructive sleep apnea, Sleep hypopnea, Sleep-disordered breathing
Plan
Vol 234
Article 107826- novembre 2024 Retour au numéro
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