To evaluate visual outcomes and patient-reported results after bilateral femtosecond-laser-assisted refractive lens exchange (RLE) with the implantation of a diffractive trifocal intraocular lens.

Prospective interventional case series.

A study of 27 patients (54 eyes) implanted with the Clareon PanOptix (Alcon) multifocal intraocular lens during femtosecond-laser-assisted RLE in a university hospital setting. The uncorrected (UDVA) and corrected (CDVA) distance visual acuity, uncorrected (UIVA) and distance-corrected (DCIVA) intermediate visual acuity at 60 cm, uncorrected (UNVA) and distance-corrected (DCNVA) near visual acuity at 40 and 33 cm were evaluated at 3 months postoperatively and compared with the preoperative values. In addition, we assessed the postoperative defocus curve, mesopic and photopic contrast sensitivity, and patient-reported spectacle independence.

The mean postoperative binocular UDVA was –0.02 ± 0.06 logMAR and CDVA was –0.11 ± 0.05 logMAR. The UIVA was –0.07 ± 0.05 logMAR and DCIVA was –0.07 ± 0.07 logMAR. The UNVA at 40 cm was 0.03 ± 0.09 logMAR and DCNVA was –0.02 ± 0.06 logMAR; and, at 33 cm UNVA was 0.14 ± 0.10 logMAR and DCNVA was 0.11 ± 0.08 logMAR. In comparison to the preoperative binocular CDVA (–0.12 ± 0.08 logMAR), no statistically significant change was observed (P = 1.0), while all the other binocular visual acuities improved (P < .01). In the mean binocular defocus curve, the visual acuity was better than 0.10 logMAR in the range between +0.5 D and –3.0 D. The mean contrast sensitivity was within the normal range, and most patients reported complete spectacle independence.

The RLE surgery improved uncorrected visual acuity at far, intermediate, and near distances without negatively affecting the CDVA. Patients achieved a high level of spectacle independence.