Postprandial interleukin-6 response in elderly with abdominal obesity and metabolic syndrome - 06/12/24
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Abstract |
Objective |
The aim of this study is to evaluate the contribution of central obesity to inflammatory responses in the postprandial state in elderly patients with and without metabolic syndrome (MetS).
Material/Methods |
We evaluated 80 elderly individuals who were distributed into three groups: MetS, abdominal obesity (AbObes) and Control, according to ATPIII criteria. Interleukin-6 (IL-6) serum concentration was measured at 0, 2, 4 and 6 hours after the ingestion of a physiological meal without an overload of fat.
Results |
Serum IL-6 increased 6 hours after the meal in all of the groups (P<0.001). Comparing the groups, there was no difference in the area under the curve (AUC) of IL-6 in the postprandial state. There was a correlation between the 6-hour changes in the concentrations of IL-6 and the homeostasis model assessment of insulin resistance (HOMA-IR) (r = 0.25, P<0.05).
Conclusion |
In this study, differences in abdominal circumference (AC) have not determined a different behavior of IL-6 in the postprandial state, despite the correlation between AC and IL-6. However, we found that, in the elderly, there is a rise in serum IL-6 at 6 hours.
Le texte complet de cet article est disponible en PDF.Key words : Aging, inflammation, fat-diet, fatty-acid, HOMA-IR
Plan
Vol 17 - N° 3
P. 206-210 - mars 2013 Retour au numéro
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