The power of serum uric acid in predicting metabolic syndrome diminishes with age in an elderly Chinese population - 06/12/24
Bienvenue sur EM-consulte, la référence des professionnels de santé.
Article gratuit.
Connectez-vous pour en bénéficier!
Abstract |
Objectives |
Although serum uric acid (sUA) is not a criterion for diagnosing metabolic syndrome (MetS), many studies have identified a positive association between sUA and MetS in patients of various ages and ethnicities. This association has not been fully established in the very elderly.
Design |
Cross-sectional and longitudinal study.
Setting and participants |
A total of 18,906 Chinese elderly aged 65 and older undergoing routine health checkups in Taiwan were enrolled.
Measurements |
Modified Adult Treatment Panel III criteria were used to define MetS. All participants were further divided into nine groups with gender specification according to age (the young-old, 65 to 74; old-old, 75 to 84; and oldest-old, 85 and over) and sUA concentration tertile (males: sUAG1, <5.7 mg/dL; sUAG2, 5.7–6.7 mg/dL; and sUAG3, > 6.7 mg/dL; females: sUAG1, <4.9 mg/dL; sUAG2, 4.9–5.9 mg/dL; and sUAG3, > 5.9 mg/dL). A cross-sectional study was first performed to determine the correlation between sUA and MetS and its components. A longitudinal study then excluded subjects with MetS at baseline to explore the risk of MetS according to sUA levels in 3 age groups.
Results |
In the cross-sectional study, we observed a graded, positive association between sUA and MetS components that diminished after age 75. Subjects with higher sUA levels had higher odds ratios (OR) for the occurrence of MetS in the young-old and old-old groups of both sexes (P <0.001) except sUAG2 males in the old-old group. However, the association diminished with age and only a higher OR was observed in sUAG2 males in the oldestold group (OR, 3.38; 95% CI, 1.11–10.30; P = 0.032). In the longitudinal study, the Kaplan–Meier plot showed that higher sUA levels were associated with a higher risk of MetS in the young-old group of both genders (P < 0.001 sUAG3 vs. sUAG1 and sUAG2). Cox regression analysis further confirmed these results (young-old group: sUAG3 HR, 1.90; 95% CI, 1.42-2.54; P < 0.001; old-old group males: HR, 2.20; 95% CI, 1.04-4.65; P = 0.039; young-old females: HR, 1.83; 95% CI, 1.38 - 2.43; P < 0.001).
Conclusions |
Higher sUA levels in the young-old group of Chinese elderly were associated with a higher risk of developing MetS. sUA levels are thus regarded as a potential tool for early diagnosis of MetS. However, this association diminished in those over 75 years of age.
Le texte complet de cet article est disponible en PDF.Keywords : Serum uric acid, metabolic syndrome, elderly
Plan
Vol 20 - N° 9
P. 912-917 - novembre 2016 Retour au numéro
Article précédent
- Food accessibility and perceptions of shopping difficulty among elderly people living alone in Japan
- Midori Ishikawa, T. Yokoyama, T. Nakaya, Y. Fukuda, Y. Takemi, K. Kusama, N. Yoshiike, M. Nozue, K. Yoshiba, N. Murayama
- Nutritional and functional status in geriatric day hospital patients–MNA short form versus full MNA
- E. Schrader, E. Grosch, T. Bertsch, C.C. Sieber, Dorothee Volkert
Bienvenue sur EM-consulte, la référence des professionnels de santé.