Transition to a More even Distribution of Daily Protein Intake is Associated with Enhanced Fat Loss during a Hypocaloric & Physical Activity Intervention in Obese Older Adults - 06/12/24
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Abstract |
Background |
Optimization of intentional weight loss in obese older adults, through preferential fat mass reduction, is challenging, as the concomitant lean mass loss may exacerbate sarcopenia. Recent studies have suggested within-day distribution of protein intake plays a role in determining body composition remodeling. Here, we assessed whether changes in within-day protein intake distribution are related to improvements in body composition in overweight/obese older adults during a hypocaloric and exercise intervention.
Methods |
Thirty-six community-dwelling, overweight-to-obese (BMI 28.0-39.9 kg/m2), sedentary older adults (aged 70.6±6.1 years) were randomized into either physical activity plus successful aging health education (PA+SA; n=15) or physical activity plus weight loss (PA+WL; n=21) programs. Body composition (by CT and DXA) and dietary intake (by three-day food records) were determined at baseline, 6-month, and 12-month follow-up visits. Within-day protein distribution was calculated as the coefficient of variation (CV) of protein ingested per defined time periods (breakfast [5:00−10:59], lunch [11:00−16:59] and dinner [17:00−1:00]). Secondary analysis was performed to determine associations between changes in protein intake distribution and body composition.
Results |
In both groups, baseline protein intake was skewed towards dinner (PA+SA: 49.1%; PA+WL: 54.1%). The pattern of protein intake changed towards a more even within-day distribution in PA+WL during the intervention period, but it remained unchanged in PA+SA. Transition towards a more even pattern of protein intake was independently associated with a greater decline in BMI (P<0.05) and abdominal subcutaneous fat (P<0.05) in PA+WL. However, changes in protein CV were not associated with changes in body weight in PA+SA.
Conclusion |
Our results show that mealtime distribution of protein intake throughout the day was associated with improved weight and fat loss under hypocaloric diet combined with physical activity. This finding provides a novel insight into the potential role of within-day protein intake on weight management in obese older people.
Le texte complet de cet article est disponible en PDF.Key words : Circadian timing of protein intake, weight, exercise, aging
Plan
| Sources of support: This work was supported by a Center for Disease Control cooperative agreement (1 U48 DP000025). ClinicalTrials.gov identifier: NCT00714506. SF is supported by the Epidemiology of Aging training grant at the University of Pittsburgh (NIA T32-AG0001810). |
Vol 24 - N° 2
P. 210-217 - février 2020 Retour au numéro
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