Coffee and tea intake might be associated with psychiatry diseases. However, it is unclear whether the effect of coffee/tea on anxiety and depression depending on the different types of proteins.

This was a cross-sectional study.

Our datasets were downloaded from online.

Phenotypic and genotypic data for coffee intake(N=376,196) and tea intake (N=376,078) were derived from UK Biobank. GWAS data of proteins (N=1,537) from neurologically relevant tissues (brain, cerebrospinal fluid (CSF) and plasma) were obtained from a recently published study.

Multivariate linear analysis was then used to evaluate the potential interaction effect between coffee/tea intake and proteins polygenetic risk score (PRS) on the risks of anxiety and depression controlling for age, sex, Townsend deprivation index (TDI), smoke, drinking and education level.

34 coffee intake-proteins interactions and 15 tea intake-proteins interactions were observed in anxiety individuals, such as coffee intake-c-Jun interaction (β=0.0169, P=4.131×10−3), coffee intake-Fas interaction (β=−0.0190, P=8.132×10−4), tea intake-sL-Selectin interaction (β=0.0112, P=5.412×10−3) and tea intake-IL-1F6 (β=0.0083, P=4.471×10−2). 25 coffee intake-proteins and 14 tea intake-proteins interactions were observed in depression individuals, including coffee intake- IL-1 sRI (β=0.0171, P=4.888×10−3) and coffee intake-NXPH1 interaction (β=0.0156, P=9.819×10−3), tea intake-COLEC12 interaction (β=0.0127, P=3.280×10−3), and tea intake-Layilin interaction (β=0.0117, P=7.926×10−3).

Our results suggested the important role of multiple proteins in neurologically relevant tissues in the associations between coffee/tea intake and psychiatry diseases, providing entry points to explore the mechanisms underlying anxiety and depression.