Accelerated Epigenetic Aging Mediates the Association between Vitamin D Levels and Knee Pain in Community-Dwelling Individuals - 17/12/24
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Abstract |
Objectives |
To examine the relationship between Vitamin D status and pain intensity and disability in individuals with and without knee pain, and to examine the role of epigenetics in this relationship.
Design |
Cross-sectional analysis of data from the UPLOAD-2 study (Understanding Pain and Limitations in OsteoArthritic Disease-2).
Participants |
189 individuals aged 45–65 years and older.
Measurements |
Serum Vitamin D levels, pain related interference and characteristic pain intensity measures, and the epigenetic clock GrimAge derived from blood analyses.
Results |
Lower Vitamin D was associated with advanced epigenetic aging (AgeAccelGrim), greater pain and disability and that (AgeAccelGrim) mediated the relationship between Vitamin D status and self-reported pain (ab = -0.0799; CI [-0.1492, -0.0237]) and disability (ab = -0.0669; CI [-0.1365, -0.0149]) outcomes.
Conclusion |
These data support the notion that lifestyle factors such as nutrition status play a key role in aging process, as well as the development and maintenance of age-related diseases such as pain. Modifying nutrition status could help promote healthy aging and reduce pain.
Le texte complet de cet article est disponible en PDF.Key words : Vitamin D, epigenetic aging, pain
Plan
Vol 26 - N° 4
P. 318-323 - avril 2022 Retour au numéro
Article précédent
- Epigenetic Clock: A Novel Tool for Nutrition Studies of Healthy Ageing
- Lingxiao He
- Association between Vitamin D Deficiency and Prognosis after Hip Fracture Surgery in Older Patients in a Dedicated Orthogeriatric Care Pathway
- V. Dauny, S. Thietart, J. Cohen-Bittan, B. Riou, F. Khiami, A. Meziere, M. Verny, J. Boddaert, L. Zerah, Cédric Villain
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