Primary hepatocellular carcinosarcoma: A case series and literature review - 12/01/25
Highlights |
• | The age of disease onset ranges from 38 to 76 years, with an average onset age of 56.5 years. |
• | Low-density or low-signal images are more prevalent in liver lesions of HCS than in other liver malignancies. |
• | HCS appears to have a monoclonal origin, and a correlation was observed between its onset, progression, and the presence of p53 mutations. |
• | For HCS treatment, the timely application of localized chemotherapy, along with targeted therapy and surgical resection after reducing the tumor extent, can help mitigate tumor side effects and potentially prolong survival. |
Abstract |
Introduction |
Hepatocellular carcinosarcoma (HCS) is a rare and aggressive liver tumor with limited clinical evidence due to its infrequency. This case series aimed to enrich the existing knowledge on the diagnosis and clinical management of HCS.
Methods |
Four patients with HCS were evaluated, focusing on their symptoms, diagnoses, treatments, and outcomes. The imaging characteristics and tumorigenesis of HCS were also investigated, highlighting the role of p53 mutations.
Results |
This case series found that timely surgery and localized chemotherapy are crucial in managing HCS. Despite the promising results of targeted therapy, its limitations were observed in some patients. The onset and progression of HCS were found to be significantly correlated with the presence of p53 mutations.
Conclusions |
This case series underscores the need for further research to improve the diagnosis and treatment of HCS and emphasizes the importance of timely surgery and localized chemotherapy in mitigating tumor side effects and potentially prolonging survival.
Le texte complet de cet article est disponible en PDF.Keywords : Hepatocellular carcinosarcoma, Case study, Tumorigenesis, p53 mutations, Targeted therapy
Plan
Vol 49 - N° 2
Article 102520- février 2025 Retour au numéro
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