Appendectomy, acute appendicitis, and gastrointestinal diseases: A Mendelian randomization study - 16/01/25
, Bo Li a, b, ⁎ Abstract |
Background |
Appendectomy is the standard treatment for acute appendicitis. However, the effects of appendectomy and acute appendicitis on gastrointestinal diseases are not fully understood.
Methods |
Genetic variants associated with appendectomy and acute appendicitis at a genome-wide significance level (P < 5.0E−08) were selected as instrumental variables. Two-sample univariate and multivariate Mendelian randomization (MR) analyses were performed to examine the independent effects of appendectomy and acute appendicitis on related gastrointestinal diseases.
Results |
Appendectomy was linked to an increased risk of colon cancer (odds ratio [OR], 1.54; 95 % confidence interval [CI], 1.15–2.07; P = 0.004; FDR-corrected P = 0.016) and a decreased risk of primary sclerosing cholangitis (OR, 0.57; 95 % CI, 0.38–0.84; P = 0.004; FDR-corrected P = 0.016). Acute appendicitis was associated with a higher risk of cholelithiasis (OR, 1.16; 95 % CI, 1.06–1.27; P = 0.002; FDR-corrected P = 0.016).
Conclusion |
This study suggested that appendectomy and acute appendicitis might affect the risk of several gastrointestinal diseases in European populations.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Appendectomy was associated with a higher risk of colon cancer in European populations. |
• | Appendectomy was linked to a lower risk of primary sclerosing cholangitis in European populations. |
• | Acute appendicitis was associated with a higher risk of cholelithiasis in European populations. |
Keywords : Appendectomy, Acute appendicitis, Causal inference, Mendelian randomization
Plan
Vol 240
Article 116107- février 2025 Retour au numéro
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