Evaluation of Inborn Errors of Immunity Among Patients with Opportunistic Pulmonary Infection - 30/01/25

Doi : 10.1016/j.ccm.2024.10.005

Rachel Husmann, MD ^a,^{^{1
Co-first authors.}}, Alice Lehman, MD ^a,^b,^{^{1
Co-first authors.}}, Ryan W. Nelson, MD, PhD ^c,^d, Alexa A. Pragman, MD, PhD ^a,^e,^⁎
^a Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, 420 Delaware Street Southeast #D416, Minneapolis, MN 55455, USA
^b Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Minnesota, 420 Delaware Street Southeast #850, Minneapolis, MN 55455, USA
^c Division of Rheumatology, Allergy & Immunology, Department of Pediatrics, University of Minnesota, Academic Office Building, 2450 Riverside Avenue South AO-10, Minneapolis, MN 55454, USA
^d Center for Immunology, University of Minnesota, 2101 6th Street Southeast, Minneapolis, MN 55454, USA
^e Division of Infectious Diseases, Department of Medicine, Minneapolis Veterans Affairs Medical Center, 1 Veterans Drive, 111F, Minneapolis, MN 55417, USA

^∗Corresponding author. Minneapolis Veterans Affairs Medical Center, Division of Infectious Diseases, Department of Medicine, 1 Veterans Drive, 111F, Minneapolis, MN 55417.Minneapolis Veterans Affairs Medical CenterDivision of Infectious DiseasesDepartment of Medicine1 Veterans Drive111FMinneapolisMN55417

Résumé

This review of immunocompromised host pneumonia as the result of inborn errors of immunity (IEI) is organized by opportunistic pulmonary pathogen. The authors identify patients who warrant an evaluation for an IEI based on their clinical presentation. Their recommendations are guided by the immune defect(s) associated with each opportunistic pulmonary infection. Physicians without expertise in immunology may begin an evaluation for IEI using the guidance provided here. Comprehensive evaluation by an immunologist may also be warranted in many instances.

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Keywords : Immunity, Innate, Cellular, Humoral, Primary immunodeficiency diseases, Opportunistic infections, Pneumonia, Immunocompromised host

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Pulmonary Infections that May Prompt an Evaluation for Inborn Errors of Immunity

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Vol 46 - N° 1

P. 61-75 - mars 2025 Retour au numéro

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Evaluation of Inborn Errors of Immunity Among Patients with Opportunistic Pulmonary Infection - 30/01/25

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