Is endoscopic submucosal dissection safe in the management of early-stage colorectal cancers? - 10/02/25
, Kamil Erozkan a, Brogan Catalano a, Daniela Allende b, Scott Steele a, Joshua Sommovilla a, Emre Gorgun aAbstract |
Background |
Endoscopic submucosal dissection (ESD) is increasingly being adopted for the treatment of early-stage colorectal cancer (CRC) lesions.
Methods |
We retrospectively analyzed patients with early-stage CRC treated between 2015 and 2023, using ESD and colectomy databases, categorizing them into three groups: ESD only (n = 24), oncological colorectal resection (OCR) only (n = 90), and OCR after ESD (n = 59). We compared pathological and oncological outcomes among these groups.
Results |
The OCR after ESD group demonstrated higher non-granular lesions, and deeper submucosal invasion compared to ESD only group. The primary OCR group showed higher 2-year overall survival compared to ESD-only group (98.9 % vs 85.6 %, p = 0.01), with no colorectal cancer-related mortality in any of the groups. Notably, 2-year disease-free survival rates were comparable across all groups (93.8 % ESD only, 88.0 % primary OCR only, and 97.8 % for OCR after ESD, p = 0.27).
Conclusion |
The current study highlights feasibility the promising potential and oncologic safety of ESD in carefully selected patients with early malignant lesions.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Study demonstrates comparable OS and DFS rates between patients treated with only-ESD and those who underwent OCR. |
• | ESD shows feasibility and oncologic safety as a potential definitive treatment for carefully selected cases of early-stage colorectal cancer. |
• | Surveillance can be an option for selected patients with poor prognostic indicators. |
Keywords : Colorectal cancer, Endoscopic submucosal dissection, Oncologic colorectal resection, Early-stage, Overall survival rate, Pathological outcomes
Plan
Vol 241
Article 116159- mars 2025 Retour au numéro
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