While pharyngitis is a common primary care complaint, evidence reveals that this diagnosis is an area where antibiotic therapy is frequently misused. Appropriate diagnosis and management of pharyngitis is crucial to ensure antimicrobial stewardship and improve patient safety and outcomes. Pharyngitis etiologies include both infectious and noninfectious sources such as bacteria, viruses, fungal organisms, trauma, irritants, laryngopharyngeal reflux, and medications. Clinicians need to obtain a thorough history and careful physical examination, along with appropriate diagnostic testing when indicated, to ensure treatment plans are targeted toward the most likely pharyngitis etiology.