COVID-19 reinfection in pregnancy: Assessment of severity and pregnancy outcomes in England - 13/02/25
, Julia Stowe a, Kevin Brown a, Jamie LopezBernal a, d, Shamez Ladhani a, c, Nick Andrews a, b, Helen Campbell a
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Summary |
Background |
Disease severity and pregnancy outcomes following SARS-CoV-2 reinfections in pregnancy are not well understood.
Methods |
We linked women aged 18 to 50 years testing positive in the community for COVID-19 between April 2021 and March 2022 to hospital, vaccine and maternal services databases. We compared hospital and intensive care unit (ICU) admission rates following infection and reinfection in pregnant and non-pregnant women, and low birthweight, prematurity and stillbirth in women infected and reinfected during pregnancy.
Results |
We identified 68,842 pregnant and 3,915,069 infected non-pregnant women. Hospital admission after SARS-CoV-2 reinfection was more common in pregnancy, especially during the third trimester (aOR= 18.56; 95% CI: 9.46 - 36.42) and was similar following reinfection or primary infection in pregnancy (aOR= 0.82; 95% CI: 0.50 - 1.33). All ICU admissions (n=49) in pregnancy occurred after primary infection with delta. There was no notable difference in adverse pregnancy outcomes after primary infection or reinfection with SARS-CoV-2 during pregnancy.
Conclusion |
Pregnant women remain at higher risk of more severe disease during reinfection compared to non-pregnant women yet; hospitalisation and ICU admissions risk were low during the omicron period. The virulence of circulating variants needs to be assessed to guide maternal COVID-19 vaccination programmes against.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Elevated risk of severe COVID-19 disease in pregnant compared to non-pregnant women. |
• | Reinfections in pregnancy are no less severe than primary infections. |
• | Adverse pregnancy outcomes risk similar following first infection or reinfection. |
• | Late pregnancy infection at increased risk of severe disease. |
• | Disease severity dependant on infective variant. |
Keywords : COVID-19, Reinfection, Pregnancy, Disease severity, Pregnancy outcomes
Plan
Vol 90 - N° 2
Article 106392- février 2025 Retour au numéro
Article précédent
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