Human papillomavirus infection is associated with increased risk of new-onset hidradenitis suppurativa: A population-based cohort study - 19/02/25
, Shao-Wei Lo, MD d, Christine Hsu, MD e, Shiu-Jau Chen, MD, PhD f, g, ⁎ , Torsten Zuberbier, MD h, i, Hui-Chin Chang, MLS j, k, l, ⁎ Abstract |
Background |
The exact cause of hidradenitis suppurativa (HS) remains unclear, although emerging research suggests a link between infectious agents and inflammatory skin diseases. The association between human papillomavirus (HPV) infection and HS development, however, has not been studied.
Objective |
The objective of this study was to evaluate the risk of incident HS in patients with HPV infection.
Methods |
Using the TriNetX research network, we conducted a retrospective cohort study of patients diagnosed with HPV and matched controls. Propensity score matching adjusted for variables like age, sex (male/female), race, body mass index, comorbidities, and lifestyle factors. The primary outcome was new-onset HS, analyzed across demographic and clinical factors. Hazard ratios with 95% confidence intervals were calculated to assess the risk.
Results |
After matching, both the HPV and control cohorts included 582,007 patients. HPV-infected individuals had a significantly higher risk of developing HS (hazard ratio: 1.356, 95% confidence interva: 1.290-1.427). This increased risk was consistent across various demographic and clinical groups. Sensitivity analyses confirmed the robustness of these findings.
Limitations |
Retrospective cohort design.
Conclusions |
HPV infection is linked to a higher risk of HS, suggesting a potential association. Further research is required to validate these results and assess their impact in different populations and clinical settings, as well as also elucidate the potential impact of other infections involved in the pathogenesis of HS.
Le texte complet de cet article est disponible en PDF.Key words : cohort, electronic medical records, epidemiology, hidradenitis suppurativa, human papillomavirus
Abbreviations used : CI, BMI, DNA, HIV, HPV, HR, HS, ICD-10-CM, IFN-γ, NF-kB, NK cell, SD, SMD, Th, TNF-α
Plan
| Drs Gau and Chen and Author Chang contributed equally. |
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| Funding sources: None. |
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| Patient consent: Written informed consent to participate in this study was not required from the participants or the participants' legal guardians/next of kin in accordance with the national legislation and the institutional requirements. |
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| IRB approval status: The TriNetX database was previously approved by the Western Institutional Review Board (Western IRB). The subsequent determination regarding the de-identification process attested on December 2020 replaced the need of Western IRB approval in TriNetX studies. Ethical approval was not required for the study involving humans in accordance with the local legislation and institutional requirements. |
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| “This retrospective study is exempt from informed consent. The data reviewed are a secondary analysis of existing data, do not involve intervention or interaction with human subjects, and are de-identified per the de-identification standard defined in Section §164.514(a) of the HIPAA Privacy Rule. The process by which the data are de-identified is attested to through a formal determination by a qualified expert as defined in Section §164.514(b) (1) of the HIPAA Privacy Rule. This formal determination by a qualified expert refreshed on December 2020.” |
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| Data availability: Data in this study were retrieved from TriNetX Research Network. All data available in the database were administrated by the TriNetX platform. Detailed information can be retrieved at the official website of the research network (trinetx.com). |
Vol 92 - N° 3
P. 444-451 - mars 2025 Retour au numéro
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