Preferred Parental Language and Neurodevelopmental Outcomes Among Infants With Acute Provoked Neonatal Seizures in the United States - 20/02/25

Doi : 10.1016/j.pediatrneurol.2024.12.010

Greta S. Peng, MD ^a, Karin Halsey, MPH ^b, Courtney J. Wusthoff, MD, MS, MD ^c, Catherine J. Chu, MD ^d, Shavonne L. Massey, MD ^e,^f, Monica E. Lemmon, MD ^g,^h, Cameron Thomas, MD, MS ⁱ, Adam L. Numis, MD ^a,^j, Giulia M. Benedetti, MD ^k, Julie Sturza, MPH ^k, Elizabeth E. Rogers, MD ^a, Linda S. Franck, RN, PhD ^a,^l, Charles E. McCulloch, PhD ^m, Janet S. Soul, MDCM ⁿ, Renée A. Shellhaas, MD, MS ^o, Sonia L. Bonifacio, MD ^p, Hannah C. Glass, MD, MAS ^i,^j,^l,^⁎
^a Department of Pediatrics, UCSF Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA
^b Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
^c Department of Neurology, UC Davis Children's Hospital, University of California Davis, Sacramento, California
^d Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
^e Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
^f Department of Neurology, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
^g Departments of Pediatrics, Duke University School of Medicine, Durham, North Carolina
^h Department of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina
ⁱ Division of Neurology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio
^j Department of Neurology and Weill Institute for Neuroscience, University of California, San Francisco, San Francisco, CA
^k Department of Pediatrics, University of Michigan, Ann Arbor, MI
^l Department of Family Health Care Nursing, University of California, San Francisco, San Francisco, CA
^m Department of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, CA
ⁿ Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts
^o Department of Neurology, Washington University in St Louis, St Louis, Missouri
^p Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University, Palo Alto, California

^∗Communications should be addressed to: Dr. Glass; Pediatric Neurology; 550-16^th Street, 5^th Floor; San Francisco, CA 94143.Pediatric Neurology550-16^th Street, 5^th FloorSan FranciscoCA94143

Abstract

Background

Parental non-English language preference (NELP) is associated with worse pediatric health outcomes. However, little is known about its relationship with developmental outcomes in infants with neonatal seizures. This study evaluated the relationship between parental NELP and neurodevelopment in a multicenter cohort of infants with neonatal seizures.

Methods

Infants in the Neonatal Seizure Registry-II were included. Parental NELP was defined by the use of a professional interpreter for research consent and survey completion. The Warner Initial Developmental Evaluation of Adaptive and Functional Skills (WIDEA-FS) assessment was conducted at age 24 months. Multivariate regression was used to examine the association between parental NELP and WIDEA-FS. Functional developmental impairment was defined as a WIDEA-FS score 2 S.D.s below the normative mean.

Results

Among 270 infants with neonatal seizures, 15 (6%) had parental NELP. Children with parental NELP had a WIDEA-FS score that was on average 13 points lower than that of infants without parental NELP (95% confidence interval [CI]: −27 to 1, P = 0.08) and over five times the odds of functional developmental impairment (odds ratio 4.9, 95% CI: 1.3 to 18.4, P = 0.017).

Conclusions

Children with parental NELP were more likely to have functional developmental impairment at age 24 months when compared with children without parental NELP. Since parental NELP does not have a biologically plausible impact on neurodevelopment it likely reflects discriminatory experiences that affect developmental opportunities. These findings highlight the importance of identifying social drivers to decrease potential gaps in neurodevelopmental attainment for children with parental NELP.

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Keywords : Neonatal seizures, Neurodevelopment, Parental language preference, Non-English language preference, Limited English proficiency, Spanish language preference, Language-related health inequities, Health equity

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Vol 164

P. 115-121 - mars 2025 Retour au numéro

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Preferred Parental Language and Neurodevelopmental Outcomes Among Infants With Acute Provoked Neonatal Seizures in the United States - 20/02/25

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