Persistent carbapenem resistance in mechanically ventilated ICU patients: A before-and-after analysis of the COVID-19 surge - 24/02/25
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Résumé |
Background |
The evolution of antimicrobial resistance among critically ill patients before, during, and after the COVID-19 surge remains unclear.
Methods |
We retrospectively analyzed critically ill mechanically ventilated adult patients admitted to 8 Brazilian hospitals from Jan 1, 2018 to Apr 30, 2023. We stratified the patients into 3 periods: pre-surge (Jan 01, 2018-Mar 01, 2020), surge (Mar 01, 2020-Oct 01, 2021), and post-surge (after October 01, 2021). Positive cultures, pathogen prevalence, and resistance rates were analyzed using rate ratios (RR) with 95% confidence intervals (CI).
Results |
Among 9,780 patients (3,718 pre-surge, 3,815 surge, 2,247 post-surge), those in surge period were younger (median: 70 vs 74 pre-surge vs 75 post surge) and had longer invasive mechanical ventilation duration (median 7 vs 5 days). Blood and respiratory cultures increased across periods (56.9 pre-surge vs 69.4 surge vs 70.4 patients/1,000 patient-days post-surge). Isolation of carbapenem-resistant gram-negatives increased during the surge (RR [95% CI]: 1.8 [1.5-2.2], decreased in post-surge (0.72 [0.6-0.9]), and remained higher than pre-surge (1.3 [1.0-1.6]). Resistance rates for Pseudomonas aeruginosa reduced in post-surge, whereas Klebsiella pneumoniae doubled during the surge, and remained elevated.
Conclusions |
Carbapenem resistance increased during the surge period. Although it decreased post-surge, it remained higher than pre-pandemic rates.
Le texte complet de cet article est disponible en PDF.Highlights |
• | 9,780 ventilated patients: 3,718 pre-COVID-19 surge, 3,815 surge, 2,247 post-surge. |
• | Carbapenem resistance rose during surge and stayed higher post-surge than pre-surge. |
• | Gram-negative isolation stayed high post-surge, Candidemia and MRSA showed no change. |
• | Stewardship programs must adapt, ensuring antimicrobial consumption control. |
Key Words : Antimicrobial resistance, Intensive Care Unit, Coronavirus, Antibiotic
Plan
| Funding/support: This work was supported by CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico), and Department of Science and Technology (DECIT) from the Brazilian Ministry of Health (grant number: 444968/2023-7); FAPERJ (Fundação Carlos Chagas Filho de Amparo à Pesquisa do Rio de Janeiro); CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior)---Finance Code 001; and Pfizer Global Medical Grants and Global Bridges at Mayo Clinic (grant number 69832333). |
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| Conflicts of interest: None to report. |
Vol 53 - N° 3
P. 320-325 - mars 2025 Retour au numéro
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