Prophylactic endoscopic vacuum therapy for stricture prevention after wide-field endoscopic submucosal dissection of superficial esophageal cancer - 01/03/25
Abstract |
Background and Aims |
Esophageal stricture is a severe adverse event after wide-field endoscopic submucosal dissection (ESD) of superficial esophageal carcinoma. This study evaluated the efficacy and safety of combining endoscopic vacuum therapy (EVT) and a budesonide orodispersible tablet (BOT) in preventing post-ESD strictures.
Methods |
This prospective case series included patients with superficial esophageal squamous cell carcinoma and adenocarcinoma who had wide-field ESD (≥75% circumference, resection length ≥50 mm). After ESD, EVT was applied immediately followed by 8 weeks of BOTs. The main outcome measurement was the incidence of post-ESD stricture.
Results |
Eleven patients underwent ESD. Of these, 81.8% had 75% to 99% circumference resected and 18.2% had a circumferential resection. EVT remained in situ for a mean of 3.5 days. No esophageal strictures were observed by the final follow-up, and no major adverse events occurred related to EVT or the BOT.
Conclusions |
The prophylactic combination of EVT and BOT is a novel and promising strategy for reducing post-ESD strictures.
Le texte complet de cet article est disponible en PDF.Abbreviations : BOT, EAC, ESD, EVT
Plan
Vol 101 - N° 3
P. 650-654 - mars 2025 Retour au numéro
Article précédent
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