The Relationship Between Hispanic Ethnicity and Outcomes for Infants Born Extremely Preterm - 10/03/25
Doi : 10.1016/j.jpeds.2025.114474
Jane E. Brumbaugh, MD 1, ⁎ 
, Carla M. Bann, PhD 2, Edward F. Bell, MD 3, Colm P. Travers, MD 4, Betty R. Vohr, MD 5, Elisabeth C. McGowan, MD 5, Heidi M. Harmon, MD, MS 3, Waldemar A. Carlo, MD 4, Susan R. Hintz, MD, MS Epi 6, Andrea F. Duncan, MD, MS 7
for the
, Carla M. Bann, PhD 2, Edward F. Bell, MD 3, Colm P. Travers, MD 4, Betty R. Vohr, MD 5, Elisabeth C. McGowan, MD 5, Heidi M. Harmon, MD, MS 3, Waldemar A. Carlo, MD 4, Susan R. Hintz, MD, MS Epi 6, Andrea F. Duncan, MD, MS 7for the
Eunice Kennedy Shriver NICHD Neonatal Research Network
Alan H. Jobe, MD, PhD, Michael S. Caplan, MD, Richard A. Polin, MD, Abbot R. Laptook, MD, Martin Keszler, MD, Angelita M. Hensman, PhD, RNC-NIC, Barbara Alksninis, RNC, PNP, Carmena Bishop, Robert T. Burke, MD, MPH, Melinda Caskey, MD, Laurie Hoffman, MD, Katharine Johnson, MD, Mary Lenore Keszler, MD, Andrea M. Knoll, Vita Lamberson, MD, Teresa M. Leach, MEd, CAES, Emilee Little, BSN, RN, Bonnie E. Stephens, MD, Elisa Vieira, BSN, RN, Lucille St. Pierre, BS, Suzy Ventura, Victoria E. Watson, MS, CAS, Anna Maria Hibbs, MD, MSCE, Michele C. Walsh, MD, MS, Nancy S. Newman, RN, Monika Bhola, MD, Allison H. Payne, MD MS, Deanne E. Wilson-Costello, MD, Bonnie S. Siner, RN, Gulgun Yalcinkaya, MD, Elizabeth Roth, PhD, William E. Truog, MD, Eugenia K. Pallotto, MD, MSCE, Howard W. Kilbride, MD, Cheri Gauldin, RN, BS, CCRC, Anne Holmes, RN, MSN, MBA-HCM, CCRC, Kathy Johnson, RN, CCRC, Allison Scott, RNC-NIC, BSN, CCRC, Prabhu S. Parimi, MD, Lisa Gaetano, RN, MSN, Brenda B. Poindexter, MD, MS, Kurt Schibler, MD, Suhas G. Kallapur, MD, Edward F. Donovan, MD, Stephanie Merhar, MD, MS, Cathy Grisby, BSN, CCRC, Kimberly Yolton, PhD, Barbara Alexander, RN, Traci Beiersdorfer, RN, BSN, Kate Bridges, MD, Tanya E. Cahill, RN, BSN, Juanita Dudley, RN, BSN, Estelle E. Fischer, MHSA, MBA, Teresa L. Gratton, PA, Devan Hayes, BS, Jody Hessling, RN, Lenora D. Jackson, CRC, Kristin Kirker, CRC, Holly L. Mincey, RN, BSN, Greg Muthig, BS, Sara Stacey, BA, Jean J. Steichen, MD, Stacey Tepe, BS, Julia Thompson, RN, BSN, Sandra Wuertz, RN, BSN, CLC, C. Michael Cotten, MD, MHS, Ronald N. Goldberg, MD, Ricki F. Goldstein, MD, William F. Malcolm, MD, Joanne Propst, RN, JD, Patricia L. Ashley, MD, PhD, Deesha Mago-Shah, MD, Mollie Warren, MD, Kathy J. Auten, MSHS, Kimberley A. Fisher, PhD, FNP-BC, IBCLC, Sandra Grimes, RN, BSN, Kathryn E. Gustafson, PhD, Melody B. Lohmeyer, RN, MSN, Matthew M. Laughon, MD, MPH, Carl L. Bose, MD, Janice Bernhardt, MS, RN, Gennie Bose, RN, Cindy Clark, RN, Jennifer Talbert, MS, RN, Diane Warner, MD, MPH, Janice Wereszczak, CPNP-AC/PC, Andrea Trembath, MD, MPH, Holly Martin, MD, Michael O'Shea, MD, MPH, Stephen D. Kicklighter, MD, Ginger Rhodes-Ryan, ARNP, MSN, NNP-BC, Donna White, BSN, RN-BC, Alexandra Bentley, MD, Laura Edwards, MD, Ravi M. Patel, MD, MSc, David P. Carlton, MD, Barbara J. Stoll, MD, Ira Adams-Chapman, MD (deceased), Ellen C. Hale, RN, BS, CCRC, Yvonne C. Loggins, RN, BSN, Ann Blackwelder, RN, MN, Diane I. Bottcher, RN, MSN, Sheena L. Carter, PhD, Salathiel Kendrick-Allwood, MD, Judith Laursen, RN, Maureen Mulligan LaRossa, RN, Colleen Mackie, BS, RT, Amy Sanders, PsyD, Irma Seabrook, RRT, Gloria Smikle, PNP, MSN, Lynn C. Wineski, RN, MS, Rosemary D. Higgins, MD, Andrew A. Bremer, MD, PhD, Michele C. Walsh, MD, MS, Stephanie Wilson Archer, MA, Gregory M. Sokol, MD, Brenda B. Poindexter, MD, MS, Anna M. Dusick, MD, FAAP (deceased), Lu Ann Papile, MD, Susan Gunn, NNP, CCRC, Faithe Hamer, BS, Heidi M. Harmon, MD, MS, Dianne E. Herron, RN, CCRC, Abbey C. Hines, PsyD, Carolyn Lytle, MD, MPH, Lucy C. Miller, RN, BSN, CCRC, Heike M. Minnich, PsyD, HSPP, Leslie Richard, RN, Lucy Smiley, CCRC, Leslie Dawn Wilson, BSN, CCRC, Jeffery Joyce, CCRC (deceased), Jon E. Tyson, MD, MPH, Matthew A. Rysavy, MD, PhD, Kathleen A. Kennedy, MD, MPH, Amir M. Khan, MD, Barbara J. Stoll, MD, Emily K. Stephens, BSN, RNC-NIC, Georgia E. McDavid, RN, Nora I. Alaniz, BS, Elizabeth Allain, MS, Julie Arldt-McAlister, RN, BSN, Fatima Boricha, MD, Katrina Burson, RN, BSN, Allison G. Dempsey, PhD, Susan E. Dieterich, PhD, Elizabeth Eason, MD, Patricia W. Evans, MD, Carmen Garcia, RN, CCRP, Charles Green, PhD, Donna Hall, RN, Beverly Foley Harris, RN, BSN, Margarita Jiminez, MD, MPH, Janice John, CPNP, Patrick M. Jones, MD, MA, M. Layne Lillie, RN, BSN, Anna E. Lis, RN, BSN, Terri Major-Kincade, MD, MPH, Karen Martin, RN, Sara C. Martin, RN, BSN, Carrie M. Mason, MA, LPA, Shannon McKee, EdS, Brenda H. Morris, MD, Tina Reddy, MD, Ricardo Mosquera, MD, MS, Kimberly Rennie, PhD, Shawna Rodgers, RN, BSN, Saba Khan Siddiki, MD, Maegan C. Simmons, RN, Daniel Sperry, RN, Patti L. Pierce Tate, RCP, Sharon L. Wright, MT (ASCP), Dinorah Zanger, PhD., Pablo J. Sánchez, MD, Leif D. Nelin, MD, Sudarshan R. Jadcherla, MD, Patricia Luzader, RN, Gail E. Besner, MD, Erna Clark, BA, Christine A. Fortney, PhD, RN, Julie Gutentag, RN, Nathalie L. Maitre, MD, PhD, Courtney Park, RN, Nehal A. Parikh, MD, Julie Shadd, BA, Margaret Sullivan, BA, Melanie Stein, BBA, RRT, Abhik Das, PhD, Marie G. Gantz, PhD, Jenna Gabrio, MPH, CCRP, Jamie E. Newman, PhD, MPH, Carolyn M. Petrie Huitema, MS, CCRP, Jeanette O'Donnell Auman, BS, Kristin M. Zaterka-Baxter, RN, BSN, CCRP, Lindsay Parlberg, BS, Amanda Lewis, Krisa P. Van Meurs, MD, Valerie Y. Chock, MD, MS Epi, David K. Stevenson, MD, Susan R. Hintz, MD, MS Epi, Marian M. Adams, MD, Dona Bahmani, MD, M. Bethany Ball, BS, CCRC, Barbara Bentley, PhD, Elizabeth Bruno, PhD, Alexis S. Davis, MD, MS Epi, Maria Elena DeAnda, PhD, Anne M. DeBattista, RN, PNP-C, PhD, Lynne C. Huffman, MD, Magdy Ismael, MD, MPH, Jean G. Kohn, MD, MPH, Casey Krueger, PhD, Janice Lowe, MD, Ryan E. Lucash, PhD, Andrew W. Palmquist, RN, BSN, Jessica Patel, PhD, Melinda S. Proud, RCP, Elizabeth N. Reichert, MA, CCRC, Barbara P. Recine, MA, Lilia Rutkowska, MA, Nicholas H. St. John, PhD, Dharshi Sivakumar, MD, Heather L. Taylor, PhD, Natalie Wager, PsyD, R. Jordan Williams, BA, Hali Weiss, MD., Ivan D. Frantz, MD, John M. Fiascone, MD, Elisabeth C. McGowan, MD, Brenda L. MacKinnon, RNC, Anne Furey, MPH, Ellen Nylen, RN, BSN, Paige T. Church, MD, Cecelia E. Sibley, MHA, PT, Ana K. Brussa, MS, OTR/L, Namasivayam Ambalavanan, MD, Myriam Peralta-Carcelen, MD, MPH, Morissa Ladinsky, MD, Fred J. Biasini, PhD, Kristy A. Domnanovich, PhD, Richard V. Rector, PhD, Monica V. Collins, RN, BSN, MaEd, Shirley S. Cosby, RN, BSN, Vivien A. Phillips, RN, BSN, Sally Whitley, MA, OTR-L, FAOTA, Tara E. McNair, RN, BSN, Sheree York Chapman, PT, DPT, MS, PCS, Chantel J. Jno-Finn, PT, DPT, Uday Devaskar, MD, Meena Garg, MD, Isabell B. Purdy, PhD, CPNP, Teresa Chanlaw, MPH, Rachel Geller, RN, BSN, Neil N. Finer, MD, Yvonne E. Vaucher, MD, MPH, David Kaegi, MD, Maynard R. Rasmussen, MD, Kathy Arnell, RNC, Clarence Demetrio, RN, Martha G. Fuller, PhD, RN, MSN, Wade Rich, BSHS, RRT, Nicolas J. Bouey, BS, Tarah T. Colaizy, MD, MPH, John A. Widness, MD, Michael J. Acarregui, MD, MBA, Jonathan M. Klein, MD, John M. Dagle, MD, PhD, Karen J. Johnson, RN, BSN, Diane L. Eastman, RN, CPNP, MA, Claire A. Goeke, RN, Mendi L. Schmelzel, MSN, RN, Jacky R. Walker, RN, Michelle L. Baack, MD, Laurie A. Hogden, MD, Megan Broadbent, RN, BSN, Chelsey Elenkiwich, RN, BSN, Megan M. Henning, RN, Dan L. Ellsbury, MD, Donia B. Campbell, RNC-NIC, Tracy L. Tud, RN, Shahnaz Duara, MD, Charles R. Bauer, MD, Ruth Everett-Thomas, RN, MSN, Sylvia Fajardo-Hiriart, MD, Arielle Rigaud, MD, Maria Calejo, MS, Silvia M. Frade Eguaras, MA, Michelle Harwood Berkowits, PhD, Andrea Garcia, MS, Helina Pierre, BA, Alexandra Stoerger, BA, Kristi L. Watterberg, MD, Janell Fuller, MD, Robin K. Ohls, MD, Sandra Sundquist Beauman, MSN, RNC-NIC, Conra Backstrom Lacy, RN, Andrea F. Duncan, MD, MScr, Mary Hanson, RN, BSN, Carol Hartenberger, MPH, RN, Elizabeth Kuan, RN, BSN, Jean R. Lowe, PhD, Rebecca A. Thomson, RN, BSN, Sara B. DeMauro, MD, MSCE, Eric C. Eichenwald, MD, Barbara Schmidt, MD, MSc, Haresh Kirpalani, MB, MSc, Aasma S. Chaudhary, BS, RRT, Soraya Abbasi, MD, Toni Mancini, RN, BSN, CCRC, Christine Catts, CRNP, Noah Cook, MD, Dara M. Cucinotta, RN, Judy C. Bernbaum, MD, Marsha Gerdes, PhD, Sarvin Ghavam, MD, Hallam Hurt, MD, Jonathan Snyder, RN, BSN, RN, Saritha Vangala, RN, MSN, Kristina Ziolkowski, CMA(AAMA), CCRP, Carl T. D'Angio, MD, Dale L. Phelps, MD, Ronnie Guillet, MD, PhD, Gary J. Myers, MD, Michelle Andrews-Hartley, MD, Julie Babish Johnson, MSW, Kyle Binion, BS, Melissa Bowman, RN, NP, Erica Burnell, RN, Cait Fallone, MA, Osman Farooq, MD, Julianne Hunn, BS, Diane Hust, MS, RN, CS, Rosemary L. Jensen, Emily Kushner, MA, Deanna Maffett, RN, Joan Merzbach, LMSW, Constance Orme, Diane Prinzing, Linda J. Reubens, RN, CCRC, Daisy Rochez, BS, MHA, Mary Rowan, RN, Premini Sabaratnam, MPH, Ann Marie Scorsone, MS, CCRC, Holly I.M. Wadkins, MA, Kelley Yost, PhD, Lauren Zwetsch, RN, MS, PNP, Satyan Lakshminrusimha, MD, Anne Marie Reynolds, MD, MPH, Michael G. Sacilowski, MAT, CCRC, Stephanie Guilford, BS, Ashley Williams, MSEd, William A. Zorn, PhD., Alison Kent, MD, Rachel Jones, Elizabeth Boylin, BA, Melissa Moreland, MEd, Emily Li, BA, Jennifer Donato, BS, Kelsey Voelker, BS, Kimberly McKee, MPH, Kelly Coleman, PsyD, Brenna Cavanaugh, PsyD, BCBA-D, Myra H. Wyckoff, MD, Luc P. Brion, MD, Charles R. Rosenfeld, MD, Pablo J. Sánchez, MD, Walid A. Salhab, MD, Roy J. Heyne, MD, Diana M. Vasil, MSN, BSN, RNC-NIC, Sally S. Adams, MS, RN, CPNP, Lijun Chen, PhD, RN, Maria M. De Leon, RN, BSN, Francis Eubanks, RN, BSN, Alicia Guzman, Gaynelle Hensley, RN, Elizabeth T. Heyne, MS, MA, PA-C, PsyD, Lizette E. Lee, RN, Melissa H. Leps, RN, Linda A. Madden, BSN, RN, CPNP, E. Rebecca McDougald, MSN, APRN, CPNP-PC/AC, Nancy A. Miller, RN, Janet S. Morgan, RN, Lara Pavageau, MD, Anna Puentez, MSN, RN, CPNP-PC, Pollieanna Sepulveda, RN, Kristine Tolentino-Plata, MS, PhD, Cathy Twell Boatman, MS, CIMI, Azucena Vera, AS, Jillian Waterbury, DNP, RN, CPAP-PC, Robin K. Ohls, MD, Bradley A. Yoder, MD, Mariana Baserga, MD, MSCI, Roger G. Faix, MD, Sarah Winter, MD, Stephen D. Minton, MD, Mark J. Sheffield, MD, Carrie A. Rau, RN, BSN, CCRC, Shawna Baker, RN, Karie Bird, RN, BSN, Jill Burnett, RNC, BSN, Susan Christensen, RNC, BSN, Laura Cole-Bledsoe, RN, Brandy Davis, RN, BSN, Jennifer O. Elmont, RN, BSN, Jennifer J. Jensen, RN, BSN, Manndi C. Loertscher, BS, CCRP, Jamie Jordan, RN, BSN, Trisha Marchant, RN, BSN, Earl Maxson, BSN, Kandace M. McGrath, BS, D. Melody Parry, RN, BSN, Brixen A. Reich, MSN, RNC, CCRC, Susan T. Schaefer, RRT, RN, BSN, Cynthia Spencer, RNC, Michael Steffen, PhD, Katherine Tice, RN, BSN, Kimberlee Weaver-Lewis, RN, MS, Kathryn D. Woodbury, RN, BSN, Karen Zanetti, RN, Erick B. Gerday, MD, Karen Osborne, RN, BSN, CCRC, Sean Cunningham, PhD, Becky Hall, APRN, Erika R. Jensen, APRN, Hena G. Mickelsen, BA, Galina Morshedzadeh, BSN, APRN, Kelly Stout, PhD, Ashley L. Stuart, PhD., T. Michael O'Shea, MD, MPH, Robert G. Dillard, MD, Lisa K. Washburn, MD, Barbara G. Jackson, RN, BSN, Nancy Peters, RN, Korinne Chiu, MA, Deborah Evans Allred, MA, LPA, Donald J. Goldstein, PhD, Raquel Halfond, MA, Carroll Peterson, MA, Ellen L. Waldrep, MS, Cherrie D. Welch, MD, MPH, Melissa Whalen Morris, MA, Gail Wiley Hounshell, PhD, Seetha Shankaran, MD, Beena G. Sood, MD, MS, Athina Pappas, MD, Girija Natarajan, MD, Katherine Abramczyk, Prashant Agarwal, MD, Monika Bajaj, MD, Rebecca Bara, RN, BSN, Elizabeth Billian, RN, MBA, Sanjay Chawla, MD, Kirsten Childs, RN, BSN, Lilia C. De Jesus, MD, Debra Driscoll, RN, BSN, Melissa February, MD, Laura A. Goldston, MA, Mary E. Johnson, RN, BSN, Geraldine Muran, RN, BSN, Bogdan Panaitescu, MD, Jeannette E. Prentiss, MD, Diane White, RT, Eunice Woldt, RN, MSN, John Barks, MD, Stephanie A. Wiggins, MS, Mary K. Christensen, BA, RRT, Martha D. Carlson, MD, PhD., Richard A. Ehrenkranz, MD (deceased), Harris Jacobs, MD, Christine G. Butler, MD, Patricia Cervone, RN, Sheila Greisman, RN, Monica Konstantino, RN, BSN, JoAnn Poulsen, RN, Janet Taft, RN, BSN, Joanne Williams, RN, BSN, Elaine Romano, MSN
1 Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN
2 Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, NC
3 Department of Pediatrics, University of Iowa, Iowa City, IA
4 Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL
5 Department of Pediatrics, Women & Infants Hospital of Rhode Island and Warren Albert Medical School of Brown University
6 Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA
7 Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
∗Reprint requests: Jane E. Brumbaugh, MD, Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First St S.W., Rochester, MN 55905.Department of Pediatric and Adolescent MedicineMayo Clinic200 First St S.W.RochesterMN55905
Abstract |
Objective |
To characterize the association between maternal ethnicity and infant survival to discharge without major morbidity.
Study design |
This is secondary analysis of a prospective cohort of infants born <27 weeks of gestation at National Institute of Child Health and Human Development Neonatal Research Network centers from 2006 through 2020. The primary outcome was survival to discharge without major morbidity (sepsis, necrotizing enterocolitis, bronchopulmonary dysplasia grade 3, intracranial hemorrhage grade ≥3, periventricular leukomalacia, and advanced retinopathy of prematurity). Outcomes were compared by ethnicity and adjusted for center, perinatal characteristics, and sociodemographic characteristics.
Results |
Of 14 029 subjects, 2155 (15%) were Hispanic, 6116 (44%) non-Hispanic Black, and 5758 (41%) non-Hispanic White. Infants of Hispanic mothers had the lowest survival to discharge without major morbidity (Hispanic 523/2099 [25%], non-Hispanic Black 1701/5940 [29%], non-Hispanic White 1494/5597 [27%], P = .002). Adjusted odds of survival without major morbidity differed between Hispanic and non-Hispanic Black (adjusted odds ratio [aOR] 0.80, 95% CI 0.69-0.93), but not between Hispanic and non-Hispanic White infants (aOR 1.07, 95% CI 0.92-1.25). At 2 years, children of non-Hispanic White mothers had the lowest incidence of neurodevelopmental impairment (Hispanic 544/1235 [44%], non-Hispanic Black 1574/3482 [45%], and non-Hispanic White 1004/3182 [32%], P < .001). Odds of impairment were greater for Hispanic than non-Hispanic White children (aOR 1.25, 95% CI 1.05-1.48) but did not differ between Hispanic and non-Hispanic Black children (aOR 0.88, 95% CI 0.74-1.04).
Conclusions |
In a multicenter cohort, infants of Hispanic mothers had lower odds of survival to discharge without major morbidity than infants of non-Hispanic Black mothers and similar odds of survival without major morbidity as infants of non-Hispanic White mothers.
ClinicalTrials.gov ID |
Generic Database: NCT00063063.
Le texte complet de cet article est disponible en PDF.Keywords : premature, social determinants of health, social drivers of health, mortality, morbidity, neurodevelopment, discharge, follow-up
Abbreviations : aOR, Bayley-III, Bayley-4, BPD, EOS, ICH, LOS, NDI, NEC, NICHD, NRN, ROP, SDOH
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Vol 279
Article 114474- avril 2025 Retour au numéro
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