Imaging Interstitial Fluids and Extracellular Matrix in Cerebrovascular Disorders : Current Perspectives and Clinical Applications - 08/04/25

Doi : 10.1016/j.nic.2025.01.001

Grant McGee Talkington, BS, MS, MS ^a,^b,^⁎,^{^{1
Co-first authorship.}} , Blake Ouvrier, BS, MS ^a,^b,^{^{1
Co-first authorship.}}, Amanda Louise White, BA, BS, MS ^c, Gregory Hall, BS, MS ^a, Meenakshi Umar, BS, PhD ^c, Gregory Jaye Bix, MD, PhD ^a,^b,^c
^a Department of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA 70112, USA
^b Tulane Brain Institute, Tulane University, New Orleans, LA 70112, USA
^c Department of Neurology, Tulane University School of Medicine, New Orleans, LA 70112, USA

^∗Corresponding author. JBJ 651 1324 Tulane Avenue, New Orleans, LA 70112.JBJ 651 1324 Tulane AvenueNew OrleansLA70112

Résumé

This article provides a comprehensive review of current neuroimaging techniques for visualizing and quantifying extracellular matrix (ECM) components and interstitial fluid (ISF) dynamics in cerebrovascular disorders. It examines how alterations in ECM composition and ISF movement patterns correlate with various cerebrovascular pathologies, including ischemic stroke, frontotemporal dementia, cerebral small vessel disease, Alzhheimer’s disease, and vascular dementia. The review emphasizes novel imaging markers specific to ECM/ISF alterations and their utility in differentiating various cerebrovascular pathologies. Special attention is given to the clinical applications of these imaging techniques for early disease detection, monitoring progression, and guiding therapeutic interventions.

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Keywords : Extracellular matrix, Interstitial fluid, Cerebrovascular disorders, Neuroimaging, Extracellular matrix components, Fluid dynamics, Disease biomarkers