DCARD checklist: A simple screening tool for Lewy body disease-related early symptoms in memory clinic - 09/04/25
, Moto Nishiguchi a, b, Mikiko Hagiwara b, Motoyuki Higa a, Shuntaro Natsume a, Takao Saida a, Noemi Endo a, Hideki Sugiyama a, Kiyoshi Sato bAbstract |
Objective |
Despite the relatively high prevalence of Lewy body disease (LBD) in over middle-aged people, physicians and patients show poor awareness of early symptoms. We examined the clinical utility of a simple checklist for screening for the early symptoms of LBD.
Methods |
We administered a 7-item screening checklist assessing the five representative early symptoms of LBD (dizziness, constipation, anosmia, REM sleep behavior disorder, and depression: the acronym is “DCARD”) to 450 consecutive individuals who visited the memory clinic at our university hospital. The aim of this retrospective study was to evaluate the usefulness of the DCARD checklist in differentiating neurocognitive disorders (NCD) due to LBD (i.e., NCD with Lewy bodies and NCD due to Parkinson's disease) from NCD due to non-LBD (e.g., Alzheimer's disease). We also associated the DCARD score with current depressive symptoms using the 15-item Geriatric Depression Scale (GDS-15).
Results |
Fifty-five participants (12.2 %) had a higher DCARD score (≥4 out of 7 points) regardless of the global cognitive level. The subgroup with higher DCARD scores had higher GDS-15 scores than the subgroup with lower DCARD scores (p < 0.001). With a DCARD cut-off score of 3/4, the sensitivity and specificity were 65 % and 95 %, respectively, for diagnosing NCD due to LBDs. Receiver operating characteristic curve analysis showed good discriminatory ability (area under the curve: 0.89).
Conclusions |
This simple LBD screening checklist may be useful as a diagnostic tool for the early diagnosis of LBD in memory clinics.
Clinical trial registry: None.
Le texte complet de cet article est disponible en PDF.Highlights |
• | A simple checklist for early symptoms of Lewy body disease has not been established. |
• | We explored the seven-item checklist for Lewy-related non-motor symptoms. |
• | The higher-scoring subgroup was more likely to have Lewy body disease. |
• | We found that this checklist has fairly good discriminatory ability (AUC 0.89). |
• | Odor, autonomic, REM sleep problems, and depression should be screened in the elderly. |
Keywords : Screening checklist, Early diagnosis, Dementia, Mild cognitive impairment, Minor neurocognitive disorder, Lewy body disease
Plan
Vol 94
P. 66-73 - mai 2025 Retour au numéro
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