Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the United States. Most cases arise from polyps, which can be detected and removed before becoming cancerous. Computed tomography colonography (CTC), also known as virtual colonoscopy, was first introduced in 1994 as a minimally invasive method for CRC screening and diagnosis. This 2025 update on CTC will focus on (1) techniques and dose reduction strategies, (2) image display methods, (3) reporting and classification systems, (4) tumor staging capabilities, (5) integration of advanced imaging techniques, and (6) cost-effectiveness and reimbursement.