Ferrets (Mustela putorius furo) commonly present with gastrointestinal disease, which can be of noninfectious and infectious origin. Clinical signs are often nonspecific, and can include lethargy, anorexia, vomiting, diarrhea, and melena. Obtaining a detailed history, followed by a thorough physical examination and systematic diagnostic approach are the key to obtaining a correct diagnosis. This review provides an overview of ferret gastrointestinal anatomy and physiology, and diagnostic approach to gastrointestinal problems in ferrets, followed by relevant gastrointestinal diseases related to the different sections of the gastrointestinal tract, including their work up and treatment.