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Nationwide multicenter prospective study on the usefulness, safety, and acceptability of colon capsule endoscopy in Japan - 23/04/25

Doi : 10.1016/j.gie.2024.11.004 
Naoki Hotta, MD, PhD 1, , Naoki Ohmiya, MD, PhD 2, , Hiroto Hiraga, MD, PhD 3, Konosuke Nakaji, MD 4, Satoshi Osawa, MD, PhD 5, Takafumi Omori, MD, PhD 6, Shoji Mitsufuji, MD, PhD 7, Naoki Hosoe, MD, PhD 8, Sadaharu Nouda, MD, PhD 9, Taku Kobayashi, MD, PhD 10, Masanao Nakamura, MD, PhD 11, Shiro Oka, MD, PhD 12, Koji Nonogaki, MD, PhD 13, Yukiko Baba, MD 14, Rieko Mukai, MD, PhD 15, Hiroshi Matsumoto, MD, PhD 16, Yuichiro Ikebuchi, MD, PhD 17, Masaaki Shimada, MD, PhD 18, Kazutomo Togashi, MD, PhD 19, Shinichi Katsuki, MD, PhD 20, Yu Sasaki, MD, PhD 21, Ryoichi Sawada, MD, PhD 22, Seiji Kawano, MD, PhD 23, Takahisa Furuta, MD, PhD 24, Hisao Tajiri, MD, PhD 25, Shinji Tanaka, MD, PhD 2
for the

ColoCam-J Study Group

  The collaborators of the ColoCam-J Study Group are as follows: Masahisa Ori, MD (Ori Clinic, Ashigarakami-gun, Kanagawa, Japan), Yuichiro Kuroki, MD (Department of Gastroenterology, Showa University Fujigaoka Hospital, Kanagawa, Japan), Junji Yamaguchi, MD (Department of Gastroenterology, Aichi Medical University School of Medicine, Yazako, Nagakute-cho, Japan), Hiroki Tanabe, MD (Asahikawa-Kosei General Hospital, Asahikawa, Japan), Nobuhiro Ikeda (Ikeda Clinic, Saga, Japan), Tomoaki Kono, MD (Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan), Yutaka Yano, MD (Department of Gastroenterology, Fukuoka University Chikushi Hospital, Chikushino, Japan), Shingo Higaki, MD (Department of Gastroenterology, St Hill Hospital, Ube, Japan), Teppei Omori, MD (Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan), Norihiro Hanabata, MD (Department of Gastroenterology Aomori Prefectural Central Hospital, Aomori, Japan), Mamoru Ito, MD (Department of Internal Medicine, Okayama Saiseikai General Hospital, Okayama, Japan), Akira Harada, MD (Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan), Hideki Mitooka, MD (Ashiya Mitooka Clinic, Ashiya, Japan), Toshio Kuwai, MD (Gastroenterology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan), Minoru Yamaoka, MD (Department of General Internal Medicine, Saitama Medical University, Saitama, Japan), Hirotsugu Sakamoto, MD (Department of Medicine, Division of Gastroenterology, Jichi Medical University, Shimotsuke, Japan), Dairi Higashi, MD (Seikohkai Hospital, Kadoma, Japan), Taiki Aoyama, MD (Department of Gastroenterology, Hiroshima City Asa Citizens Hospital, Hiroshima, Japan), Mikinori Koga, MD (Department of Gastroenterology, Musashi-Murayama Hospital, Tokyo, Japan), Wataru Honda, MD (Brother Kinen Hospital, Nagoya, Japan), Junichi Sato, MD (Japan Community Health Care Organization Kani Tohno Hospital, Kani, Japan).
Masahisa Ori 27, Yuichiro Kuroki 28, Junji Yamaguchi 29, Hiroki Tanabe 30, Nobuhiro Ikeda 31, Tomoaki Kono 32, Yutaka Yano 33, Shingo Higaki 34, Teppei Omori 35, Norihiro Hanabata 36, Mamoru Ito 37, Akira Harada 38, Hideki Mitooka 39, Toshio Kuwai 40, Minoru Yamaoka 41, Hirotsugu Sakamoto 42, Dairi Higashi 43, Taiki Aoyama 44, Mikinori Koga 45, Wataru Honda 46, Junichi Sato 47
27 Ori Clinic, Ashigarakami-gun, Kanagawa, Japan 
28 Department of Gastroenterology, Showa University Fujigaoka Hospital, Kanagawa, Japan 
29 Department of Gastroenterology, Aichi Medical University School of Medicine, Yazako, Nagakute-cho, Japan 
30 Asahikawa-Kosei General Hospital, Asahikawa, Japan 
31 Ikeda Clinic 
32 Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan 
33 Department of Gastroenterology, Fukuoka University Chikushi Hospital, Chikushino, Japan 
34 Department of Gastroenterology, St Hill Hospital, Ube, Japan 
35 Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan 
36 Department of Gastroenterology Aomori Prefectural Central Hospital Aomori Japan 
37 Department of Internal Medicine, Okayama Saiseikai General Hospital, Okayama, Japan 
38 Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 
39 Ashiya Mitooka Clinic 
40 Gastroenterology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan 
41 Department of General Internal Medicine, Saitama Medical University, Saitama, Japan 
42 Department of Medicine, Division of Gastroenterology, Jichi Medical University, Shimotsuke, Japan 
43 Seikohkai Hospital 
44 Department of Gastroenterology, Hiroshima City Asa Citizens Hospital, Hiroshima, Japan 
45 Musashi-Murayama Hospital 
46 Brother Kinen Hospital, Nagoya, Japan 
47 Japan Community Health Care Organization Kani Tohno Hospital, Kani, Japan 

1 Department of Internal Medicine, Masuko Memorial Hospital, Nagoya, Japan, Department of Advanced Endoscopy, Fujita Health University School of Medicine, Toyoake, Japan 
2 Departments of Gastroenterology and Advanced Endoscopy, Fujita Health University School of Medicine, Toyoake, Japan 
3 Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan 
4 Endoscopy Center, Aishinkai Nakae Hospital, Wakayama, Japan 
5 Endoscopic and Photodynamic Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan 
6 Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Japan 
7 Department of Gastroenterology, Kyoto Kujo Hospital, Kyoto, Japan 
8 Center for Preventive Medicine, Keio University, Tokyo, Japan 
9 Second Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Osaka, Japan 
10 Center for Advanced IBD Research and Treatment, Kitasato University, Kitasato Institute Hospital, Tokyo, Japan 
11 Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan 
12 Department of Gastroenterology, Hiroshima University Hospital, Hiroshima, Japan 
13 Department of Gastroenterology, Daido Hospital, Nagoya, Japan 
14 Department of Gastroenterology, Nanpuh Hospital, Kagoshima, Japan 
15 Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan 
16 Division of Internal Medicine, Department of Gastroenterology, Kawasaki Medical School, Kurashiki, Japan 
17 Department of Multidisciplinary Internal Medicine, Division of Gastroenterology and Nephrology, Faculty of Medicine, Tottori University, Yonago, Japan 
18 Department of Gastroenterology, NHO Nagoya Medical Center, Nagoya, Japan 
19 Department of Coloproctology, Aizu Medical Center, Fukushima Medical University, Fukushima, Japan 
20 Department of Gastroenterology Otaru Ekisaikai Hospital, Hokkaido, Japan 
21 Department of Gastroenterology, Faculty of Medicine, Yamagata University, Yamagata, Japan 
22 Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan 
23 Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan 
24 Center for Clinical Research, Hamamatsu University School of Medicine, Hamamatsu, Japan 
25 Department of Innovative Interventional Endoscopy Research, The Jikei University School of Medicine, Tokyo, Japan 

Reprint requests: Naoki Ohmiya, MD, PhD, Department of Gastroenterology, Department of Advanced Endoscopy, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Toyoake, Aichi 470-1192, Japan.Department of GastroenterologyDepartment of Advanced EndoscopyFujita Health University School of Medicine1-98 Kutsukake-choToyoakeAichi470-1192Japan

Abstract

Background and Aims

We determined the factors influencing total capsule colonoscopy, adequate cleansing, and detectability of second-generation colon capsule endoscopy (CCE) for colorectal polyps or tumors (CRTs), adverse events, and acceptability.

Methods

Among 44 Japanese hospitals, 1006 patients with suspected or documented colorectal diseases who underwent CCE were enrolled prospectively.

Results

The total capsule colonoscopy rate was 86.1%. Age younger than 63 years (adjusted odds ratio [aOR], 1.525), male sex (aOR, 1.496), inflammatory bowel disease (aOR, 1.889), lavage intake on day –1 (aOR, 1.625), ≥1800-mL lavage intake on day 0 (aOR, .595), prokinetics on day 0 (aOR, .608), and ≥30-mL castor oil booster on day 0 (aOR, 1.734) were significant independent predictors. The overall adequate cleansing rate was 65.5%. Constipation (aOR, .527), lavage intake on day –1 (aOR, 1.822), laxative intake on day –1 (aOR, 2.616), and ≥1900-mL lavage intake on day 0 (aOR, 1.449) were significant independent predictors. The detection rates for patients with CRTs ≥6 mm and ≥10 mm were 92% (95% confidence interval, 84-97) and 89% (95% confidence interval, 78-96), respectively. Inadequate cleansing in the ascending colon (aOR, .184), ≥6-mm CRT in the transverse colon (aOR, 4.703), and ≥6-mm CRT in the left-sided colon (aOR, 32.013) were significant independent predictors. CCE retention occurred in 2 patients (.20%) requiring endoscopic and surgical interventions. In total, 63% of patients desired CCE for their next colonoscopy.

Conclusions

CCE was relatively safe, well tolerated, and useful for detecting colorectal lesions when adequate bowel preparation was made. (Clinical trial registration number: UMIN000021936.)

Le texte complet de cet article est disponible en PDF.

Graphical abstract




Le texte complet de cet article est disponible en PDF.

Abbreviations : aOR, CCE, CI, CRT, IBD, OR, PEG, UC


Plan


 DIVERSITY, EQUITY, AND INCLUSION: We worked to ensure gender balance in the recruitment of human subjects. The author list of this paper includes contributors from the location where the research was conducted who participated in the data collection, design, analysis, and/or interpretation of the work.


© 2025  American Society for Gastrointestinal Endoscopy. Publié par Elsevier Masson SAS. Tous droits réservés.
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