Diagnostic and discriminative accuracy of plasma phosphorylated tau 217 for symptomatic Alzheimerʼs disease in a Chinese cohort - 27/04/25
, Tao Liu e, ⁎ , Nan Zhang a, ⁎
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Highlights |
• | A reference interval of plasma p-tau217 measured with a single-molecule array (Simoa) was established for Chinese individuals. |
• | Plasma p-tau217 demonstrated exceptional diagnostic accuracy for AD even at early stages. |
• | Plasma p-tau217 could efficiently differentiate AD patients from either FTLD patients or SIVD patients. |
• | There was a negative correlation between plasma p-tau217 level and memory ability in symptomatic AD patients. |
Abstract |
Background |
Plasma phosphorylated tau at threonine 217 (p-tau217) measured with an ultrasensitive immunoassay method has been demonstrated to be an optimal biomarker for Alzheimer's disease (AD).
Objectives |
The aim of this study was to establish the reference interval for plasma p-tau217 in Chinese individuals and evaluate its diagnostic value in symptomatic AD.
Design, setting, participants |
We recruited 150 cognitively unimpaired (CU) individuals, 60 patients with AD dementia, 30 patients with mild cognitive impairment (MCI) due to AD, 40 patients with frontotemporal lobar degeneration (FTLD), and 70 patients with subcortical ischaemic vascular dementia (SIVD).
Measurements |
The concentrations of plasma p-tau217, total tau, amyloid-beta (Aβ)42 and Aβ40 were measured with a single-molecule array.
Results |
Plasma p-tau217 outperformed other biomarkers in discriminating AD patients from CU controls, FTLD patients, and SIVD patients (AUC = 0.983, 0.936, 0.892) and discriminating MCI patients from CU controls (AUC = 0.943). The plasma p-tau217 level was negatively correlated with memory in patients with symptomatic AD.
Conclusion |
The diagnostic accuracy of plasma p-tau217 was exceptional for AD, even at early stages, in the Chinese population.
Le texte complet de cet article est disponible en PDF.Keywords : Phosphorylated tau, Amyloid-β, Plasma biomarkers, Alzheimer's disease, Reference interval
Plan
Vol 12 - N° 5
Article 100092- mai 2025 Retour au numéro
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