Psychiatric Pharmacogenomic Testing : A Primer for Clinicians - 08/05/25

Doi : 10.1016/j.psc.2025.01.004

Lisa C. Brown, PhD ^a, Gwyneth Zai, PhD, MD ^b,^c,^d, James L. Kennedy, MD ^b,^c,^d, Daniel J. Müller, MD, PhD ^c,^e,^f,^g, Emytis Tavakoli, MD ^c, Chad Bousman, PhD, MPH ^h,^i,^j,^k,^l,^m, Abdullah Al Maruf, PhD, MPharm ^k,^l,^n,^o,^p,^⁎
^a Great Scott!, Surf City, North Carolina, USA
^b Tanenbaum Centre for Pharmacogenetics, Neurogenetics Section, Molecular Brain Sciences Research Department, Campbell Family Mental Health Research Institute, 250 College St, Toronto, Ontario M5T 1R8, Canada
^c Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
^d Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
^e Pharmacogenetics Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
^f Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Wurzburg, Wurzburg, Germany
^g Ontario Shores Centre for Mental Health Sciences, Whitby, Ontario, Canada
^h Department of Medical Genetics, University of Calgary, 3330 Hospital Dr NW, Calgary, Alberta T2N 4N1, Canada
ⁱ Department of Physiology & Pharmacology, University of Calgary, Alberta, Canada
^j Department of Community Health Sciences, University of Calgary, Alberta, Canada
^k The Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
^l Department of Psychiatry, University of Calgary, Alberta, Canada
^m Alberta Children’s Hospital Research Institute, University of Calgary, Alberta, Canada
ⁿ College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, 750 McDermot Avenue West, Winnipeg, Manitoba R3E 0T5, Canada
^o Department of Psychiatry, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
^p The Children’s Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada

^∗Corresponding author. College of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada.College of PharmacyUniversity of ManitobaWinnipegManitobaCanada

Résumé

Pharmacogenomic (PGx) testing is an evidence-based strategy to optimize the selection and dosing of certain psychotropic medications. An individual’s genetics play a role in medication response through pharmacokinetic and pharmacodynamic mechanisms. The current evidence base of psychiatric PGx mainly focuses on the metabolism of psychotropics through the cytochrome P450 (CYP) system. PGx testing and decision support tools are not yet standardized, resulting in variations in interpretation and prescribing recommendations. Clinicians are encouraged to use PGx results as part of the clinical picture, in addition to the patient’s overall clinical profile, in determining a personalized treatment plan for their patients.

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Keywords : Pharmacogenomics, Pharmacogenetics, Psychiatry, Precision medicine, Mental health, Implementation

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Current Evidence Base and State of Implementation in Psychiatry

Clinical Practice Guidelines

Responsible Use of Psychiatric Pharmacogenomic Testing

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Vol 48 - N° 2

P. 257-264 - juin 2025 Retour au numéro

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Psychiatric Pharmacogenomic Testing : A Primer for Clinicians - 08/05/25

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