The ethics of psychiatric genetics and genomics is an emerging field, distinct from general genetics. Key ethical concerns include the implications for personhood and identity, the dual perception of psychiatric conditions as both afflictions and integral aspects of identity, and the unique vulnerabilities of affected populations regarding informed consent. The multifactorial nature of psychiatric disorders, characterized by complex genetic and environmental interactions, further complicates ethical considerations. This paper explores ethical issues in psychiatric genomic research, clinical applications, and prevention efforts, emphasizing the need for a multidisciplinary approach and the importance of context sensitivity, particularly in low-and-middle-income countries.