Is there an association between inflammatory biomarkers and organ space surgical site infection after emergency laparotomy in massively transfused trauma patients? - 14/05/25
Abstract |
Background |
The relationship between inflammatory biomarkers (IB) and organ space surgical site infections (OS-SSIs) after emergency laparotomy (EL) is poorly understood.
Methods |
Retrospective, single-center analysis of patients in the Pragmatic, Randomized Optimal Platelet and Plasma Ratios (PROPPR) trial who underwent EL and survived 48 h after admission was performed. IB levels of IL-6, IL-8, G-CSF, MCP-1, neutrophil to lymphocyte ratio, and platelet to lymphocyte ratio were analyzed. IB and OS-SSIs association was evaluated using the Wilcoxon rank sum test.
Results |
Of 74 eligible patients, 80 % were male, 69 % sustained blunt trauma, the injury severity score was 31 (24–41), and 22 % developed OS-SSIs. Levels of IL-6 (12, 24 h), IL-8 (2, 12, 24, 72 h), and MCP-1 (24 h) were higher in OS-SSI patients (P < 0.05).
Conclusions |
IL-6, IL-8, and MCP-1 levels were associated with OS-SSIs in PROPPR patients who underwent EL. The IB may help to predict high-risk patients for OS-SSIs.
Le texte complet de cet article est disponible en PDF.Graphical abstract |
Highlights |
• | Association between biomarkers and organ space surgical site infections (OS-SSIs). |
• | Association between level of MCP-1, IL-6, and IL-8 and OS-SSI in trauma patients. |
• | Biomarkers levels correlated with critical times in the patients' resuscitation. |
• | Inflammatory biomarkers may help to predict high-risk patients for OS-SSIs. |
Plan
Vol 244
Article 116106- juin 2025 Retour au numéro
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