Tape-strip profiling identifies unique immune and lipid dysregulation in patients with seborrheic dermatitis - 19/05/25
Abstract |
Background |
Seborrheic dermatitis (SD) is a common, chronic inflammatory skin disease with limited understanding of its pathophysiology. Molecular profiling has been limited by invasiveness of sampling methods.
Objective |
To analyze the molecular skin profile of adult patients with SD using tape strips.
Methods |
Tape-strips obtained from facial lesions of 26 adult SD patients and 18 demographically matched healthy controls were evaluated with RNA sequencing.
Results |
SD molecular skin fingerprint was characterized by strong and significant upregulation of interleukin (IL)23/T-helper (Th)17 and Th22 (i.e. IL23A, IL22, PI3, LL37, S100A8, S100A12), some Th1 skewing (OASL, STAT1, CXCL9), and limited Th2 modulation. A parallel downregulation of barrier markers (CLDN1/8, FA2H, ELOVL3) was also observed.
Limitations |
Limited representation of mild and severe SD patients.
Conclusion |
These data deepen our understanding of SD suggesting that it has robust Th17/Th22, some Th1 skewing, and minimal Th2 activation, and associated skin barrier alterations. This provides rationale for novel immunomodulatory treatment approaches for SD patients targeting IL23/Th17 and/or Th22 pathways.
Le texte complet de cet article est disponible en PDF.Key words : atopic dermatitis, face, facial, IL-17, IL-23, IL-36, profiling, psoriasis, seb derm, seborrheic dermatitis, tape strip, tape-strip, tape-stripping, Th17, Th22, transcriptomic
Abbreviations used : AD, BC, DEG, FCH, FDA, FDR, GSVA, HC, IGA, IL, PSO, SD, Th
Plan
| Funding sources: Funding for this study was provided by Arcutis Biotherapeutics, Inc. This work was also supported by the Icahn School of Medicine Clinical Translational Science Award (UL1TR004419) TL-1 program. |
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| Patient consent: The authors attest to obtaining written patient consent for the publication of recognizable patient photographs or other identifiable material, with the understanding that this information may be publicly available. |
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| IRB approval status: Reviewed and approved by the institutional review board of the Icahn School of Medicine at Mount Sinai. |
Vol 92 - N° 6
P. 1277-1287 - juin 2025 Retour au numéro
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