Nailfold capillaroscopy data in acute coronary syndromes - 21/05/25
, Taha Yassine Jabloun 1, Faida Ajili 2, Bilel Arfaoui 3, Nour Gueddiche 2, Sarra Chenik 1, Houaida Mahfoudhi 1, Nadia Abdelhafidh 2, Abdedayem Haggui 1, Nadhem Hajlaoui 1, Wafa Fehri 1
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Résumé |
Introduction |
Endothelial dysfunction plays a crucial role in atherosclerosis. Nailfold capillaroscopy, a non-invasive method, allows for the exploration of microcirculation at the microscopic level. Although recent studies have established links between capillaroscopic abnormalities and certain metabolic diseases, the connection between these abnormalities and the severity of coronary lesions remains controversial and underexplored.
Objective |
Our objective was to evaluate this relationship in patients with acute coronary syndrome.
Method |
This was a prospective, monocentric, descriptive study conducted over a period of ten months, including 74 patients admitted for acute coronary syndrome (ACS). They were divided into two groups based on the Syntax I score (SSI) and into two groups based on the Gensini score (GS). All patients underwent nailfold capillaroscopy within the first 48hours.
Results |
The average age of the study population was 61±10 years, with a male predominance (sex ratio of 3.6). Overweight and smoking were the most common cardiovascular risk factors (63 and 60%, respectively), and unstable angina was the most frequent reason for hospitalization (47%). The median Syntax I score (SSI) was 11.5 [6.7–19], with an intermediate-to-high SSI observed in 16% of the total population. The capillaroscopic score was significantly higher and positively correlated, serving as an independent predictive factor for an intermediate-to-high SSI; a value≥6 predicted severe coronary artery disease with a sensitivity of 81% and a specificity of 61%. The median Gensini score (GS) was 27.5 [16.5–48.5], with a high score observed in 37% of the total population. The capillaroscopic score was also significantly higher and positively correlated, serving as an independent predictive factor for a high GS; a value≥6 predicted severe coronary artery disease with a sensitivity of 70% and a specificity of 60%.
Conclusion |
The capillaroscopic score was an independent predictive factor for severe coronary lesions. Thus, capillaroscopy could serve as a simple and non-invasive tool to identify patients at risk of severe coronary lesions or coronary artery disease.
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Vol 118 - N° 6-7S1
P. S179 - juin 2025 Retour au numéro
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