Retroperitoneal well-differentiated liposarcoma (WDLPS) and dedifferentiated liposarcoma (DDLPS) are rare tumors presenting as bulky abdominal tumors requiring multidisciplinary management in high-volume centers. Surgery is the mainstay of treatment through complete en bloc resection with the goal of achieving macroscopically complete resection, with a single specimen encompassing the tumor and involved contiguous organs. Preoperative radiation therapy is not standard of care and the role of preoperative chemotherapy is under investigation. If the tumor is not resectable or metastatic, the preferred treatment is doxorubicin-based chemotherapy in the case of DDLPS, whereas WDLPS are generally thought of as chemo-resistant.