The Immunobiological Functions and Therapeutic Applications of Interleukin-17 Family in Cancer - 02/07/25

Doi : 10.1016/j.retram.2025.103527

Nasrin Mansuri ¹, Asma'a H. Mohamed ^2,^⁎ , Marya Ahsan ³, Sana Abdul-Jabbar Ali ⁴, Mohammed Ansar Qureshi ⁵, Waleed Aldhaaban ⁶, Ayaz Khurram Mallick ⁷, Muataz Elsiddig Dafaalla Mohammed ⁸, Fuzail Ahmad ⁹, Irshad Ahmad ¹⁰, Mohammad Chand Jamali ¹¹, Alaa Shafie ¹²
¹ Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
² Department of Optometry Techniques, Technical College Al-Mussaib, Al-Furat Al-Awsat Technical University, Najaf, Iraq.
³ Department of Pharmacology, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13317, Saudi Arabia.
⁴ Pharmacy Department, Al Safwa University College, Karbala, Iraq.
⁵ College of Medicine, Najran University, Najran, Saudi Arabia
⁶ Department of Ophthalmology, College of Medicine, King Khalid University, Abha P.O.Box 61421, Saudi Arabia.
⁷ Department of Clinical Biochemistry, College of Medicine, King Khalid University, Abha, Saudi Arabia.
⁸ Department of Physiology, College of Medicine, King Khalid University, Abha, Saudi Arabia.
⁹ Respiratory Care Department, College of Applied Sciences, Almaarefa University, Diriya, Riyadh 13713, Saudi Arabia.
¹⁰ Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
¹¹ Faculty of Medical and Health Sciences, Liwa College, Al Ain, Abu Dhabi, UAE.
¹² Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O.Box 11099, Taif 21944, Saudi Arabia.

^⁎Corresponding author: Department of Optometry Techniques, Technical College Al-Mussaib, Al-Furat Al-Awsat Technical University, Najaf, Iraq.Department of Optometry TechniquesTechnical College Al-MussaibAl-Furat Al-Awsat Technical UniversityNajafIraq

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Abstract

Interleukin-17 (IL-17) family cytokines play a pivotal role in immune responses and inflammatory processes, significantly impacting various physiological and pathological conditions. This review explores the immunobiological functions of IL-17, focusing on its diverse cellular sources, including T helper 17 (Th17) cells, γδ T cells, innate lymphoid cells (ILCs), neutrophils, and natural killer T (NKT) cells, and signaling pathways. Special attention is given to IL-17 involvement in cancer, where it exhibits both pro-tumorigenic and anti-tumorigenic effects, influencing tumor proliferation, angiogenesis, metastasis, and drug resistance through various signaling cascades such as JAK/STAT, NF-κB, and PI3K/AKT. Understanding these mechanisms highlights IL-17 as a potential therapeutic target for modulating immune responses and improving cancer treatments.

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Keywords : IL-17, Th17, tumor, cytokine, cancer immunotherapy, tumor microenvironment