Bleeding is a common presentation in patients with cancer. Hemorrhage may result from ongoing low-volume oozing, episodic major bleeding, or acute catastrophic bleeding. Resuscitating critically ill patients involves airway management and volume resuscitation with blood products. Bleeding should be immediately controlled with pressure, packing, and local hemostatic agents. Endoscopic or surgical interventions may be required to control persistent bleeding. Emergency medicine providers should prioritize the patient’s care goals when making clinical management decisions.