Fracture-related infections are challenging complications in orthopedic care, marked by infection at fracture or surgical sites, often involving biofilm-associated pathogens. They result in significant morbidity, prolonged hospitalizations, and high health care costs. Diagnosis integrates clinical, laboratory, and imaging findings, while treatment combines surgical debridement, implant management, and targeted antimicrobial therapy. Common pathogens include Staphylococcus aureus and Staphylococcus epidermidis, with culture-negative cases requiring advanced diagnostics. A multidisciplinary approach is critical to optimizing outcomes, addressing complications, and reducing the socioeconomic impact of these infections. Advances in treatment strategies continue to improve survival and quality of life for affected patients.