This article addresses medication-related problems (MRPs) in hospitals, which continue to cause substantial preventable harm. Medication errors (ME), adverse drug reactions, and adverse drug events remain prevalent, significantly impacting patient safety. The article highlights the importance of medication reconciliation, especially during care transitions, and the challenges posed by polypharmacy. It also explores technological advancements, such as clinical decision support systems and artificial intelligence, in reducing ME. Additionally, it examines the medication-related effects of emerging trends like the Hospital at Home model. The article underscores the need for continuous improvement in medication safety practices to reduce preventable harm.