Multi-omics profiling and molecular pathways in esophageal adenocarcinoma - 01/08/25
, Yu Wu a, b, c, ⁎ Highlights |
• | Molecular Characterization of EAC: Comprehensive analysis of genetic, transcriptomic, metabolic, and microenvironmental alterations in esophageal adenocarcinoma (EAC). |
• | Integration of Multi-Omics Data: A holistic approach combining genomics, transcriptomics, metabolomics, and tumor microenvironment studies to elucidate EAC pathogenesis. |
• | Identification of Key Biomarkers and Therapeutic Targets: Discovery of crucial molecular alterations provides novel strategies for targeted therapy. |
• | Advancements in Precision Medicine: Multi-omics approaches offer transformative potential for improving EAC diagnosis, prognosis, and personalized treatment. |
Abstract |
Esophageal adenocarcinoma (EAC) is an aggressive malignancy with a rising incidence and poor prognosis. This review integrates current insights into the molecular features of EAC, focusing on the application of multi-omics approaches to unravel its genetic, transcriptomic, metabolic, and microenvironmental alterations. By identifying key biomarkers and therapeutic targets, we highlight the transformative potential of multi-omics in advancing precision medicine for EAC.
Le texte complet de cet article est disponible en PDF.Keywords : Esophageal adenocarcinoma, Multi-omics, Molecular mechanisms, Biomarkers, Precision medicine, Tumor microenvironment
Plan
Vol 49 - N° 8
Article 102653- septembre 2025 Retour au numéro
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