Associations between sarcopenia operationalized using muscle strength or power and health-related parameters - 04/08/25

Doi : 10.1016/j.tjfa.2025.100062

Hélio José Coelho Júnior ^a,^b,^c,^d,^⁎ , Alejandro Álvarez-Bustos ^c,^d,^e, Riccardo Calvani ^a,^b, Stefano Cacciatore ^a, Anna Picca ^a,^f, Matteo Tosato ^a,^b, Francesco Landi ^a,^b, Emanuele Marzetti ^a,^b,^⁎
on behalf of the
Lookup Study Group^¹
Study members and their affiliations appear at the end of the paper.
Francesco Landi ^a,^b, Roberto Bernabei ^a, Emanuele Marzetti ^a,^b, Riccardo Calvani ^a,^b, Luca Mariotti ^a, Stefano  Cacciatore ^a,^b, Hélio José Coelho-Junior ^a,^b, Francesca Ciciarello ^b, Vincenzo Galluzzo ^b, Anna Maria Martone ^a,^b, Anna Picca ^b,^c, Andrea Russo ^b, Sara Salini ^b, Matteo Tosato ^b, Gabriele Abbatecola ^a, Clara Agostino ^a, Fiorella Ambrosio ^a, Francesca Banella ^a, Carolina Benvenuto ^a, Damiano Biscotti ^b, Vincenzo Brandi ^b, Maria Modestina Bulla ^a, Caterina Casciani ^a, Lucio Catalano ^b, Camilla Cocchi ^a,^b, Giuseppe Colloca ^b, Federica Cucinotta ^a, Emanuela D’Angelo ^b, Mariaelena D’Elia ^b, Federica D’Ignazio ^a,^b, Daniele Elmi ^a, Marta Finelli ^a, Francesco Pio Fontanella ^a, Domenico Fusco ^b, Ilaria Gattari ^a, Giordana Gava ^a,^b, Tommaso Giani ^a,^b, Giulia Giordano ^a,^b, Rossella Giordano ^a,^b, Francesca Giovanale ^a, Simone Goracci ^a, Silvia Ialungo ^a,^b, Rosangela Labriola ^a,^b, Elena Levati ^a,^b, Myriam Macaluso ^a,^b, Luca Marrella ^a, Claudia Massaro ^a,^b, Rossella Montenero ^a,^b, Maria Vittoria Notari ^a, Maria Paudice ^a, Martina Persia ^a, Flavia Pirone ^a, Simona Pompei ^b, Rosa Ragozzino ^a, Carla Recupero ^a, Antonella Risoli ^a,^b, Stefano Rizzo ^a,^b, Daria Romaniello ^a, Giulia Rubini ^a, Barbara Russo ^a, Stefania Satriano ^a, Giulia Savera ^a, Elisabetta Serafini ^b, Annalise Serra Melechì ^b, Francesca Simeoni ^a, Sofia Simoni ^a,^b, Chiara Taccone ^a, Elena Tagliacozzi ^a, Roberta Terranova ^a, Salvatore Tupputi ^a, Matteo Vaccarella ^a, Emiliano Venditti ^a, Chiara Zanchi ^a, Maria Zuppardo ^a
^a Department of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, L.go F. Vito 1, 00,168 Rome, Italy
^b Fondazione Policlinico Universitario “Agostino Gemelli” IRCCS, L. go A. Gemelli 8, 00,168 Rome, Italy
^c Department of Medicine and Surgery, LUM University, Strada Statale 100 km 18, 70,100 Casamassima, Italy

^a Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
^b Department of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, Rome, Italy
^c Biomedical Research Center Network for Frailty and Healthy Ageing (CIBERFES), Institute of Health Carlos III, Madrid, Spain
^d Department of Geriatrics, Hospital Universitario de Getafe, Madrid, Spain
^e Instituto de Investigación IdiPaz, Madrid, Spain
^f Department of Medicine and Surgery, LUM University, Casamassima, Italy

^⁎Corresponding authors: Department of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, L.go F. Vito 1, Rome 00168, Italy.Department of GeriatricsOrthopedics and RheumatologyUniversità Cattolica del Sacro CuoreL.go F. Vito 1Rome00168Italy

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Highlights

•	Sarcopenic indexes capture different health parameters;.
•	Muscle power improves the associations of sarcopenia with health parameters;.
•	Sarcopenia operationalized according to muscle power displays exclusive and stronger associations with health parameters.

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Abstract

Background and Objectives

The present study examined the associations between sarcopenia, operationalized through muscle strength or muscle power, and health parameters in Italian community-dwelling older adults.

Design

Cross-sectional study.

Setting

Unconventional settings across Italy.

Participants

Italian older adults (65+ years) who provided a written informed consent.

Measurements

Physical function was evaluated according to isometric handgrip strength (IHG) and 5-time sit-to-stand (5STS) performances. Muscle power parameters were estimated based on 5STS values. Sarcopenia was operationalized according to the presence of low physical function (i.e., IHG or 5STS), or low muscle power, plus low appendicular skeletal muscle mass. Health parameters included the capacity to perform the 400 m test, adherence to the Mediterranean (MED) diet, practice of physical activity (PA), blood pressure (BP) values, blood concentration of total cholesterol and glucose, verbal fluency, sleep quality, and self-reported health status.

Results

Results indicated that sarcopenic indexes had a poor-to-moderate level of agreement. Moreover, results indicated that operationalizing sarcopenia using muscle power measures provided exclusive or stronger associations with health parameters. Specifically, older adults classified as sarcopenic based on muscle power values were less likely to complete the 400-meter walk test, more likely to engage in PA, reported poorer self-rated health, and showed lower adherence to the MED diet.

Conclusions

Findings of the present study indicated that sarcopenia indexes based on muscle strength or muscle power capture different aspects of older adults’ health. Specifically, operationalizing sarcopenia using muscle power measures provided exclusive or stronger associations with health parameters.

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Keywords : Frailty, Disability, Mobility, Physical performance, Intrinsic capacity, Mediterranean diet

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Vol 14 - N° 4

Article 100062- août 2025 Retour au numéro

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Associations between sarcopenia operationalized using muscle strength or power and health-related parameters - 04/08/25

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Abstract

Background and Objectives

Design

Setting

Participants

Measurements

Results

Conclusions

Plan

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