A Multisite Randomized Controlled Trial of Hand Arm Bimanual Intensive Training Including Lower Extremity for Children with Bilateral Cerebral Palsy - 12/08/25
, Yannick Bleyenheuft, PhD 2, Iona Novak, PhD 3, 4, Catherine Elliott, PhD 5, 6, Sarah Reedman, PhD 1, 4, Catherine Morgan, PhD 4, Kerstin Pannek, PhD 7, Natalie Dos Santos, PhD 1, Ashleigh Hines, PhD 4, Sherilyn Nolan, BPT 5, 8, Robert S. Ware, PhD 9, Roslyn N. Boyd, PhD 1Abstract |
Objective |
To test the efficacy of Hand Arm Bimanual Intensive Therapy Including Lower Extremity (HABIT-ILE) to improve gross motor function, manual ability, goal performance, walking endurance, mobility, and self-care for children with bilateral cerebral palsy.
Study design |
This prospective, waitlist randomized controlled trial included children with bilateral cerebral palsy, aged 6-to-16-years and classified Gross Motor Function Classification System levels II to IV. HABIT-ILE delivered for 2 weeks (65 hours) was compared with usual care. Primary outcomes postintervention were gross motor function (Gross Motor Function Measure-66) and manual ability (ABILHAND-Kids). Secondary outcomes were goal performance (Canadian Occupational Performance Measure), self-care and mobility (Pediatric Evaluation of Disability Inventory-Computer Adapted Test), bimanual hand performance (Both Hands Assessment), and walking endurance (6 Minute Walk Test). Linear regression models were used to determine between group differences, adjusted for baseline scores.
Results |
Ninety-two children were recruited; 2 were deemed ineligible after randomization and were excluded. Ninety children (HABIT-ILE n = 46, usual care n = 44), mean age 10.4 (SD 3.0) years, Gross Motor Function Classification System II = 32; III = 31; IV = 27 were included. HABIT-ILE led to superior gains in manual ability (mean difference 0.85, 95% CI 0.38-1.33; P < .001) but not gross motor function. HABIT-ILE led to superior changes on goal performance, self-care, and mobility.
Conclusions |
HABIT-ILE was effective in improving manual ability, mobility, self-care, and goal performance, but not gross motor function. Significant gains were immediately retained at 26 weeks postintervention. Large individual variability suggests further analyses need to be performed to understand characteristics of children who achieved clinically meaningful gains across outcomes.
Trial registration |
Australian and New Zealand Clinical Trials Registry (ACTRN12618000164291).
Le texte complet de cet article est disponible en PDF.Keywords : cerebral palsy, motor training, rehabilitation, children
Abbreviations : CFCS, CP, CP-QOL, GMFCS, HABIT-ILE, MACS, UC
Plan
| European Academy of Childhood Disability Meeting, May 29-June 1 2024, Bruges, Belgium; Australasian Academy of Cerebral Palsy and Developmental Medicine Meeting July 31-August 3rd, 2024, Cairns Australia; American Academy of Cerebral Palsy and Developmental Medicine September 10-13 2023, Chicago USA. |
Vol 284
Article 114666- septembre 2025 Retour au numéro
Article précédent
- Neonatal Critical Illness, 8-Year White Matter Microstructure, and Motor Function in Children Born Very Preterm
- Sarvenaz Oloomi, Steven Ufkes, Thiviya Selvanathan, Cecil Chau, Elke Roland, Ting Guo, Vann Chau, Ruth E. Grunau, Steven P. Miller
- Machine-Learning Assisted Screening with FIND FH for Familial Hypercholesterolemia among Youth
- Kerrilynn C. Hennessey, Mary P. McGowan, Hanyuan Shi, Terry Sturke, Roshni S. Kalkur, Adam J. Prince, Shoshana H. Bardach, Nichole M. Rogovoy, Marc A. Hofley
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?