Early Infancy Weight Gain Patterns Are Associated with Child Body Mass Index in Singletons but Not Twins - 04/09/25
, Byron A. Foster, MD, MPH 1, 2, Miguel Marino, PhD, MS 1, 3, Jonathan M. Snowden, PhD 1, 4, Rachel Springer, MS 3, Janne Boone-Heinonen, PhD, MPH 1, †Abstract |
Objective |
To assess the relationship between characteristics of infant weight trajectory and child body mass index (BMI) in twins compared with singletons.
Study design |
Data were extracted from the PROMISE study, an electronic health record-based cohort of pregnant individuals and their children born from 2004 to 2020 across community-based health care organizations in the United States. We compared 227 and 250 male and female twins with 13 952 and 13 500 male and female singletons, respectively, and secondary comparison groups of 2270 male and 2500 female singletons matched to twins on gestational age and sex. Infant weight trajectory (0-24 months) was modeled with the Jenss model. Linear regression was used to determine associations between weight trajectory characteristics and BMI z-score (BMIz) at 3 and 5 years within each group.
Results |
Among twins, only late infancy weight gain (∼12-24 months) was positively associated with BMIz at 3 and 5 years, with a stronger association among female compared with male twins. In contrast, among singletons, starting weight, early infancy weight gain (∼0-6 months), mid-infancy weight gain (∼6-12 months), and late infancy weight gain (∼12-24 months) were associated with BMIz at 3 and 5 years. Associations among GA-matched singletons were similar to the full singleton group.
Conclusions |
Among twins, early and mid-infancy weight gains were not associated with child BMIz, with only late infancy weight gain showing an association. In contrast, among singletons, all parameters of infant weight trajectory were associated with child BMIz. These findings suggest different drivers of infant weight gain and childhood BMI in twins and singletons.
Le texte complet de cet article est disponible en PDF.Keywords : twins, weight gain, body-weight trajectory, body mass index, electronic health records
Abbreviations : ADVANCE, BMI, BMIz, CI, EHR, GA, GWG, ICD, PCORnet, PROMISE, RIWG, SD, US
Plan
Vol 285
Article 114687- octobre 2025 Retour au numéro
Article précédent
- The Mini-COMET Clinical Trial: Safety and Efficacy of Avalglucosidase Alfa after 97 Weeks of Treatment in Children with Infantile-Onset Pompe Disease Previously Treated with Alglucosidase Alfa
- David Kronn, James Davison, Alexander Broomfield, Anaïs Brassier, François Labarthe, Si Houn Hahn, Satoko Kumada, Hirotaka Ohki, Sasapin Grace Prakalapakorn, Catherine Wilson, Kristina An Haack, Olivier Huynh-ba, Susan Richards, Susan Sparks, Swathi Tammireddy, Tianyue Zhou, Yin-Hsiu Chien, Priya S. Kishnani, Mini-COMET investigators
- Testing Higher Doses of Sildenafil to Repair Brain Injury Secondary to Birth Asphyxia: An Open-Label Dose-Finding Phase 1b Clinical Trial–Sildenafil Administration to Treat Neonatal Encephalopathy–Study 02
- Pia Wintermark, Anie Lapointe, Gabriel Altit, Robin Steinhorn, Emmanouil Rampakakis, Andreas D. Meid, Jürgen Burhenne, Gzona Bajraktari-Sylejmani, May Khairy, Marie-Therese Adamo, Guillaume Gilbert, Daniela Toffoli, Samara Zavalkoff, Thuy Mai Luu, Elizabeth Hailu, Walter E. Haefeli
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?