Chronotype has been defined according to an individual's preference regarding the timing for daily activities and behaviors such as waking up, eating, exercising and going to bed. These behavioral preferences have been related to genetic, endocrine, behavioral, and other biological, psychological, environmental, and social traits. Research in chronobiology has linked the "morning" vs. "evening" preference to different risk for several health problems. The assessment of our current knowledge of chronotype and its influence on the development and persistence of the current pandemic of obesity and metabolism-related chronic diseases is timely and relevant. The present narrative review aims to examine the available evidence regarding chronotype and metabolic health. We also discuss the potential use of chronotype-based therapeutic approaches in clinical practice and describe literature gaps to propose future research directions in this field. Understanding molecular, physiological, psychological, and social mechanisms underlying differences between "larks" and "owls" will provide the opportunity to translate this knowledge into clinical practice and may be vital to implementing and/or improving individualized treatment outcomes.