Higher Distressed Communities Index is associated with more aggressive features in papillary thyroid cancer - 09/09/25
, Alexandra Helbing b, Rachel Stemme a, Darci Foote a, Jennine Weller a, Mingzhao Xing c, d, Lilah F. Morris-Wiseman a, Aarti Mathur aAbstract |
Background |
We sought to identify associations between living in an economically distressed community and the oncologic features and mutational status of papillary thyroid cancer (PTC).
Methods |
Patients with PTC were identified retrospectively. Community distress was estimated using the Distressed Communities Index (DCI). Logistic regression was used to assess associations between DCI, oncologic features, and tumor mutational status.
Results |
Among 1062 patients, those from “at risk” (9.6%) or “distressed” (7.1%) communities were more likely to have tumors >4 cm (aOR 2.13, 95% CI 1.15–3.95), experience disease recurrence (aOR 1.84, 95% CI 1.16–2.91), and die due to thyroid cancer (aOR 3.56, 95% CI 1.26–10.05) compared to those in “prosperous” (41.6%) communities. No associations were found between DCI and tumor mutations or multifocality.
Conclusions |
Patients from “distressed” communities are diagnosed with more advanced thyroid cancer with higher rates of recurrence and death despite no differences in tumor mutational profile.
Le texte complet de cet article est disponible en PDF.Graphical abstract |
Highlights |
• | The impact of socioeconomic factors on PTC tumor mutational status is unknown. |
• | Patients from “distressed” communities have worse outcomes, regardless of mutations. |
• | DCI independently predicts larger tumors, recurrence, and mortality for PTC patients. |
• | DCI may serve as a more relevant predictor of PTC outcomes than race alone. |
Keywords : Papillary thyroid cancer, Tumor mutations, Distressed communities index, Economic distress, Thyroid cancer outcomes
Plan
| ☆ | Meeting details: AAES 44th Annual Meeting 2024. Apr 20–22, 2024. Dallas, Texas. |
Vol 248
Article 116520- octobre 2025 Retour au numéro
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