SARS-CoV-2 PCR and antibody positivity in asymptomatic health care workers with a known SARS-CoV-2 exposure: December, 2020 to December, 2021 - 13/09/25

Doi : 10.1016/j.ajic.2025.07.005

Rachel Yoken, BA ^a, Caroline A. O’Neil, MA, MPH ^a, Kate Peacock, MPH ^a, Candice Cass, BS ^a, Meghan A. Wallace, BS ^b, Kelly Alvarado, BS ^b, Mostafa Amor, BS ^a, Emily Struttmann, BA ^a, Daniel Park, BS ^a, David McDonald, BA ^a, Karl Hock, BA ^b, Hilary Babcock, MD, MPH ^a, Carey-Ann D. Burnham, PhD ^b, Christopher W. Farnsworth, PhD ^b, Jennie H. Kwon, DO, MSCI ^a,^⁎
^a Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO
^b Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO

^⁎Address correspondence to Jennie H. Kwon, DO, MSCI, Washington University School of Medicine, Division of Infectious Diseases, 4253 Clayton Ave Box 8051, St. Louis, MO 63110.Washington University School of Medicine, Division of Infectious Diseases4253 Clayton Ave Box 8051St. LouisMO63110

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Résumé

In this prospective cohort study, 30 health care personnel with a known SARS-CoV-2 exposure provided oropharyngeal swabs for polymerase chain reaction (PCR) testing and blood specimens for serologic testing at 2 time points postexposure. At a median 7days postexposure (range, 1-13days), none had a positive PCR and 1 (3%) had a reactive antibody test. No additional participants were PCR or antibody-positive at a median 25days postexposure (range, 14-36days).

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Highlights

•	This study focused on 30 health care personnel with recent, known COVID-19 exposure.
•	Participants underwent SARS-CoV-2 PCR and serologic antibody testing.
•	Only 1 participant (3%) had a reactive antibody test; none had a PCR.

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Key Words : Vaccination, Health care personnel

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	Conflicts of interest: None to report.
	Funding/support: This study was supported by the US Centers for Disease Control and Prevention (contract no. 75D30121C10185). The funding agency had no role in the study design, in the collection, analysis, or interpretation of study data, in the writing of the report, or in the decision to submit the article for publication.

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Vol 53 - N° 10

P. 1124-1126 - octobre 2025 Retour au numéro

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SARS-CoV-2 PCR and antibody positivity in asymptomatic health care workers with a known SARS-CoV-2 exposure: December, 2020 to December, 2021 - 13/09/25

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