Antidepressant usage and its postoperative outcomes on the surgical management of basal cell carcinomas: A propensity-matched cohort analysis - 18/09/25
, Ayaan Sohail, BS b, Amir Alsaidi, BS a, Matthew Dallo, MD c, Misha V. Koshelev, MD, PhD cAbstract |
Background |
Patients undergoing basal cell carcinoma (BCC) surgery often have coexisting psychiatric comorbidities and are often managed with antidepressants (ADPs). Despite the efficacy associated with the use of ADPs, there is limited research exploring the impact of ADPs on the outcomes of patients undergoing surgical management for BCC.
Objective |
This study evaluates the impact of ADP usage on postoperative outcomes and complications in those receiving surgery for BCC.
Methods |
Utilizing the TriNetX database, BCC patients were matched on a 1:1 basis according to ADP status. Outcome variables were evaluated over a 90-day follow-up period.
Results |
In a matched sample of 3197 patients, those on ADPs exhibited significantly higher rates of opioid prescriptions at 90 days (34.7% vs 17.5%; P < .001). Surgical site infection (1.7% vs 0.9%; P < .003), wound disruption (1.4% vs 0.6%; P < .001), hospital readmissions (8.3% vs 2.5%; P < .001), sepsis (1% vs 0.3%; P < .002), inpatient hospitalization (9.9% vs 3.3%; P < .001), and emergency department visits (9.2% vs 4.4%; P < .001) were also significantly higher in the ADP group at 90 days.
Conclusion |
Patients on ADPs undergoing BCC surgery experience higher risks of opioid use, surgical site infection, wound disruption, hospital readmissions, sepsis, inpatient hospitalization, and emergency department visits.
Le texte complet de cet article est disponible en PDF.Key words : antidepressant, basal cell carcinoma, complications, dermatologic surgery, risk factors, surgery
Abbreviations used : ADPs, BCC, SSRis, TCAs
Plan
| Funding sources: None. |
|
| Patient consent: Not applicable. |
|
| IRB approval status: Not applicable. |
Vol 93 - N° 4
P. 993-999 - octobre 2025 Retour au numéro
Article précédent
- Molecular and immunophenotypic profiling of leukemia cutis in acute myeloid leukemia: A retrospective matched-cohort study
- Grant Z. Zhao, Samantha Guhan, Walter J. Liszewski, Cuong V. Nguyen
- Disease modification in psoriasis through early interleukin 17 inhibitor intervention: A retrospective cohort study
- Junchen Chen, Guo Zhou, Yang Sha, Jingge Xiao, Chen Chen, Wenyu Deng, Ruixuan Wang, Xiang Chen, Chengzhi Lv, Yehong Kuang
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?